López María J, Carbajal Junior, Alfaro Alejandro L, Saravia Luis G, Zanabria Daniel, Araujo Jhajaira M, Quispe Lidia, Zevallos Alejandra, Buleje José L, Cho Cristina Eunbee, Sarmiento Marisol, Pinto Joseph A, Fajardo Williams
Facultad de Biología, Universidad Nacional San Luis Gonzaga de Ica, Ica, Peru.
Departmento de Patología, Hospital Nacional Dos de Mayo, Lima, Peru.
Crit Rev Oncol Hematol. 2023 Jan;181:103841. doi: 10.1016/j.critrevonc.2022.103841. Epub 2022 Oct 11.
Gastric cancer is one of the most important malignancies in the world due to the high burden of disease and lethality. In this work, we compared the main characteristics of gastric cancer between different regions of the world. We reviewed public repositories to retrieve epidemiological, molecular, clinicopathological, and risk factor data. Eastern Asia presents the highest incidence of gastric cancer, followed by eastern and central Europe. Intestinal histology was more frequent in Caucasians, while gastric tumors located in the cardias were less frequent in Africa and Latin America. TP53, LRP1B, and ARID1A are consistently the most frequently altered genes in all population groups. Gastric cancer is most frequent in men. African patients tend to be younger and have a higher proportion of women patients. Different patterns can be observed in the presentation of gastric cancer between different regions of the world. More research is needed in Latin America and Africa since these populations are underrepresented.
由于疾病负担和致死率高，胃癌是世界上最重要的恶性肿瘤之一。在这项研究中，我们比较了世界不同地区胃癌的主要特征。我们查阅了公共数据库以获取流行病学、分子、临床病理和风险因素数据。东亚地区胃癌发病率最高，其次是东欧和中欧。高加索人肠道组织学类型更为常见，而非洲和拉丁美洲贲门部的胃肿瘤较少见。TP53、LRP1B和ARID1A始终是所有人群组中最常发生改变的基因。胃癌在男性中最为常见。非洲患者往往更年轻，女性患者比例更高。世界不同地区胃癌的表现存在不同模式。拉丁美洲和非洲的研究较少，因为这些人群的代表性不足，所以需要更多研究。
