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结核性脑膜炎患者抗结核治疗的反常反应

Paradoxical Reaction to Antitubercular Treatment in a Case of Tuberculous Meningitis.

作者信息

Perera Solangaratchige Don Harshana Sameera

机构信息

Respiratory Medicine, Central Chest Clinic, Colombo, LKA.

出版信息

Cureus. 2023 Aug 26;15(8):e44151. doi: 10.7759/cureus.44151. eCollection 2023 Aug.

DOI:10.7759/cureus.44151
PMID:37753002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10519641/
Abstract

Tuberculous meningitis (TBM) is a challenging disease to treat, as  infects the meninges, which are the outer membranes of the brain and the spinal cord. The majority of patients diagnosed with TBM acquire various other central nervous system complications, and as a result, treating the disease becomes a challenging task. A paradoxical reaction to the treatment may occur in the course of managing TBM. This case study describes a 20-year-old Southeast Asian female who was diagnosed and treated for TBM and subsequently developed a resurgence of the disease due to a paradoxical reaction.

摘要

结核性脑膜炎(TBM)是一种难以治疗的疾病,因为它会感染脑膜,即大脑和脊髓的外层膜。大多数被诊断为TBM的患者会出现各种其他中枢神经系统并发症,因此,治疗这种疾病成为一项具有挑战性的任务。在TBM的治疗过程中可能会出现对治疗的矛盾反应。本病例研究描述了一名20岁的东南亚女性,她被诊断患有TBM并接受了治疗,随后由于矛盾反应导致疾病复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ec/10519641/a18b987b85b9/cureus-0015-00000044151-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ec/10519641/a18b987b85b9/cureus-0015-00000044151-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7ec/10519641/a18b987b85b9/cureus-0015-00000044151-i01.jpg

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本文引用的文献

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Corticosteroid therapy for the management of paradoxical inflammatory reaction in patients with pulmonary tuberculosis.皮质类固醇治疗肺结核患者的矛盾性炎症反应。
Infection. 2020 Aug;48(4):641-645. doi: 10.1007/s15010-020-01430-7. Epub 2020 Apr 24.
2
Treatment of Tuberculous Meningitis and Its Complications in Adults.成人结核性脑膜炎及其并发症的治疗
Curr Treat Options Neurol. 2018 Feb 28;20(3):5. doi: 10.1007/s11940-018-0490-9.
3
High mortality associated with retreatment of tuberculosis in a clinic in Kampala, Uganda: a retrospective study.
乌干达坎帕拉一家诊所中与结核病再治疗相关的高死亡率:一项回顾性研究
Am J Trop Med Hyg. 2015 Jul;93(1):73-5. doi: 10.4269/ajtmh.14-0810. Epub 2015 May 4.
4
Paradoxical and bidirectional drug effects.矛盾和双向药物效应。
Drug Saf. 2012 Mar 1;35(3):173-89. doi: 10.2165/11597710-000000000-00000.
5
FNAC in tuberculous lymphadenitis: experience from a tertiary level referral centre.细针穿刺抽吸活检术在结核性淋巴结炎中的应用:来自三级转诊中心的经验
Indian J Tuberc. 2011 Jul;58(3):102-7.
6
Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy.
Am J Respir Crit Care Med. 2001 Jul 1;164(1):7-12. doi: 10.1164/ajrccm.164.1.2101133.