INRS-Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada.
Front Immunol. 2023 Sep 11;14:1269391. doi: 10.3389/fimmu.2023.1269391. eCollection 2023.
Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many galectins preferentially exist in cytosolic and nuclear compartments, which is consistent with the fact that they are exported outside the cells via a yet undefined non-classical mechanism. This review summarizes our most recent knowledge of their intracellular functions in cancer cells and provides some directions for future strategies to inhibit their role in cancer progression.
尽管人们已经关注细胞外半乳糖凝集素在调节肿瘤生长和转移方面的作用（积极或消极），但我们也越来越关注细胞内半乳糖凝集素在应对其环境方面的作用。这并不奇怪，因为许多半乳糖凝集素优先存在于细胞质和核区室中，这与它们通过尚未定义的非经典机制被运出细胞的事实是一致的。这篇综述总结了我们对半乳糖凝集素在癌细胞中的细胞内功能的最新认识，并为未来抑制其在癌症进展中作用的策略提供了一些方向。
