Laboratory of Glycobiology, The Noguchi Institute, 1-9-7, Kaga, Itabashi, Tokyo 173-0003, Japan.
Int J Mol Sci. 2024 Sep 23;25(18):10231. doi: 10.3390/ijms251810231.
Lectin-based approaches remain a valuable tool for analyzing glycosylation, especially when detecting cancer-related changes. Certain glycans function as platforms for cell communication, signal transduction, and adhesion. Therefore, the functions of glycans are important considerations for clinical aspects, such as cancer, infection, and immunity. Considering that the three-dimensional structure and multivalency of glycans are important factors for their function, their binding characteristics toward lectins provide vital information. Glycans and lectins are inextricably linked, and studies on lectins have also led to research on the roles of glycans. The applications of lectins are not limited to analysis but can also be used as drug delivery tools. Moreover, mammalian lectins are potential therapeutic targets because certain lectins change their expression in cancer, and lectin regulation subsequently regulates several molecules with glycans. Herein, we review lectin-based approaches for analyzing the role of glycans and their clinical applications in diseases, as well as our recent results.
基于凝集素的方法仍然是分析糖基化的有价值的工具，特别是在检测与癌症相关的变化时。某些糖链作为细胞通讯、信号转导和黏附的平台发挥作用。因此，糖链的功能是临床方面（如癌症、感染和免疫）的重要考虑因素。鉴于糖链的三维结构和多价性是其功能的重要因素，它们与凝集素的结合特性提供了重要信息。糖链和凝集素是密不可分的，对凝集素的研究也导致了对糖链作用的研究。凝集素的应用不仅限于分析，还可以用作药物递送工具。此外，哺乳动物凝集素是潜在的治疗靶点，因为某些凝集素在癌症中改变其表达，而凝集素的调节随后调节了几种带有糖链的分子。本文综述了基于凝集素的方法在分析糖链作用及其在疾病中的临床应用，以及我们的最新研究结果。
