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地诺单抗相关的人工关节周围非典型股骨骨折：一例报告

Denosumab-associated Periprosthetic Atypical Femur Fracture: A Case Report.

作者信息

Abe Satomi, Inoue Masahiro, Mikami Takashi, Kanno Taiki, Masuda Takeshi

机构信息

Department of Orthopedic Surgery, Eniwa Hospital, 2-1-1 Koganechuou Eniwa 061-1449, Japan.

出版信息

J Orthop Case Rep. 2023 Sep;13(9):29-32. doi: 10.13107/jocr.2023.v13.i09.3864.

DOI:10.13107/jocr.2023.v13.i09.3864
PMID:37753145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10519314/
Abstract

INTRODUCTION

Denosumab is generally used for 5-10 years to treat postmenopausal osteoporosis. Although atypical fractures caused by bisphosphonate use are well known, reports of denosumab-associated femur fractures are rare.

CASE REPORT

Herein, a 75-year-old woman suffered an atypical periprosthetic femoral fracture 31 months after receiving denosumab. The fracture occurred transverse to the stem tip with lateral cortical thickening. The patient underwent revision surgery for conversion to a longer cemented stem. The fracture site healed 10 months after revision surgery.

CONCLUSION

As far as we know, there have been no reports of a case on periprosthetic atypical femur fracture associated with denosumab. Our study shows the potential of periprosthetic atypical femoral fractures in patients using denosumab for a long time.

摘要

引言

地诺单抗通常用于治疗绝经后骨质疏松症5至10年。虽然使用双膦酸盐导致的非典型骨折广为人知，但关于地诺单抗相关股骨骨折的报道却很少。

病例报告

在此，一名75岁女性在接受地诺单抗治疗31个月后发生了非典型假体周围股骨骨折。骨折发生在柄尖横向处，伴有外侧皮质增厚。患者接受了翻修手术，更换为更长的骨水泥柄。翻修手术后10个月骨折部位愈合。

结论

据我们所知，尚无关于地诺单抗相关假体周围非典型股骨骨折病例的报道。我们的研究显示了长期使用地诺单抗的患者发生假体周围非典型股骨骨折的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/3defc0d3e7fc/JOCR-13-29-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/e4b6cf8035c1/JOCR-13-29-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/2edc781869b4/JOCR-13-29-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/23f3f22bae5a/JOCR-13-29-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/00b4fe2c49d7/JOCR-13-29-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/3defc0d3e7fc/JOCR-13-29-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/e4b6cf8035c1/JOCR-13-29-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/2edc781869b4/JOCR-13-29-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/23f3f22bae5a/JOCR-13-29-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/00b4fe2c49d7/JOCR-13-29-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b76/10519314/3defc0d3e7fc/JOCR-13-29-g005.jpg

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J Arthroplasty. 2021 Jul;36(7):2597-2602. doi: 10.1016/j.arth.2021.02.048. Epub 2021 Feb 23.
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