Department of Dermatology, INHA University School of Medicine, Incheon, South Korea.
Clinical Trial Division, Human Co., Ltd. Skin Clinical Trial Center, Seoul, South Korea.
Skin Res Technol. 2023 Sep;29(9):e13452. doi: 10.1111/srt.13452.
High-intensity focused ultrasound (HIFU) and radiofrequency (RF) are non-invasive modalities for skin rejuvenation, but their combined effects have not been evaluated.
We evaluated and compared the efficacy of HIFU alone and combined HIFU and bipolar RF using a newly designed probe.
Twenty-two Korean adults with facial wrinkles and aging underwent treatment on both sides of their face: HIFU-only on the left and HIFU combined with RF on the right. Skin parameters were measured at different time points to evaluate the improvement in skin rejuvenation.
HIFU treatment significantly improved skin parameters, including pore volume and number, skin elasticity, depth of eye wrinkles, degree of sagging in the eye area, nasolabial folds and cheeks, volume of the jawline, skin density, and permittivity. Furthermore, combining bipolar RF with HIFU treatment enhanced efficacy in reducing pore number, improving skin elasticity, diminishing eye wrinkle depth, and increasing skin moisturization. These findings indicate that bipolar RF can synergically improve skin rejuvenation by providing a thermal effect to the upper papillary dermis, which is more superficial than the target area of HIFU.
Combining HIFU with bipolar RF synergistically improves skin rejuvenation, including pore reduction, periorbital wrinkle improvement, skin elasticity, and skin moisturization.
高强度聚焦超声（HIFU）和射频（RF）是用于皮肤年轻化的非侵入性方式，但它们的联合效果尚未得到评估。
我们使用新设计的探头评估和比较了单独使用 HIFU 以及联合使用 HIFU 和双极 RF 的效果。
22 名有面部皱纹和老化的韩国成年人在他们的面部两侧接受治疗：左侧仅进行 HIFU 治疗，右侧进行 HIFU 联合 RF 治疗。在不同时间点测量皮肤参数，以评估皮肤年轻化的改善情况。
HIFU 治疗显著改善了皮肤参数，包括毛孔体积和数量、皮肤弹性、眼周皱纹深度、眼周下垂程度、鼻唇沟和脸颊、下颌线体积、皮肤密度和介电常数。此外，将双极 RF 与 HIFU 治疗相结合可以增强减少毛孔数量、改善皮肤弹性、减少眼周皱纹深度和增加皮肤保湿的效果。这些发现表明，双极 RF 可以通过为比 HIFU 目标区域更浅的上乳头真皮层提供热效应，从而协同改善皮肤年轻化。
HIFU 联合双极 RF 协同改善皮肤年轻化，包括减少毛孔、改善眶周皱纹、增加皮肤弹性和保湿。
