Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Hum Vaccin Immunother. 2023 Aug;19(2):2261199. doi: 10.1080/21645515.2023.2261199. Epub 2023 Sep 27.
A 20-month-old girl was diagnosed with Guillain - Barré syndrome (GBS) based on progressive muscle weakness, areflexia, and albuminocytologic dissociation of the cerebrospinal fluid. Despite timely and systematic treatment, she eventually became paralyzed. There is a temporal correlation between the girl's GBS and the DTaP vaccination, but the exact causal relationship between the two is still debatable. Furthermore, we summarized clinical features of other 45 published GBS cases after DTP vaccines (or vaccine substances containing tetanus) through a systematic review. The mean onset age, sex distribution, onset time after vaccination, detection of antiganglioside antibodies, and other basic clinical features of GBS after DTP vaccination (or vaccine substances containing tetanus) were analyzed. The temporal pattern of GBS after vaccination was similar to that of GBS after infection. Herein, we report this rare case of presumptive pediatric GBS after DTaP vaccination and review similar cases to draw the attention of medical personnel to similar events after vaccination. An association between DTP vaccines and GBS has been proposed, and the causal relationship between these two incidents are worthy further exploration. Moreover, surveillance and vigilance for GBS after vaccination are highly recommended.
一个 20 个月大的女孩因进行性肌无力、反射消失和脑脊液蛋白细胞分离而被诊断为格林-巴利综合征（GBS）。尽管及时进行了系统治疗，她最终还是瘫痪了。女孩的 GBS 与 DTaP 疫苗接种之间存在时间相关性，但两者之间的确切因果关系仍存在争议。此外，我们通过系统评价总结了其他 45 例 DTP 疫苗（或含破伤风疫苗成分）接种后发生的 GBS 的临床特征。分析了 DTP 疫苗（或含破伤风疫苗成分）接种后 GBS 的平均发病年龄、性别分布、接种后发病时间、抗神经节苷脂抗体检测等基本临床特征。接种疫苗后 GBS 的发病模式与感染后 GBS 的发病模式相似。在此，我们报告了一例罕见的 DTaP 疫苗接种后疑似儿童 GBS 病例，并对类似病例进行了回顾，以引起医务人员对疫苗接种后类似事件的关注。已经提出 DTP 疫苗与 GBS 之间存在关联，这两起事件之间的因果关系值得进一步探讨。此外，强烈建议对疫苗接种后的 GBS 进行监测和警惕。
