Martynenko Natalia, Anisimova Natalia, Shinkareva Maria, Rybalchenko Olga, Rybalchenko Georgy, Zheleznyi Mark, Lukyanova Elena, Temralieva Diana, Gorbenko Artem, Raab Arseny, Pashintseva Natalia, Babayeva Gulalek, Kiselevskiy Mikhail, Dobatkin Sergey
A.A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, 119334 Moscow, Russia.
N.N. Blokhin National Medical Research Center of Oncology (N.N. Blokhin NMRCO) of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia.
Biomimetics (Basel). 2023 Sep 3;8(5):408. doi: 10.3390/biomimetics8050408.
The structure, phase composition, corrosion and mechanical properties, as well as aspects of biocompatibility in vitro and in vivo, of a Zn-1%Mg-0.1%Dy alloy after equal-channel angular pressing (ECAP) were studied. The structure refinement after ECAP leads to the formation of elongated α-Zn grains with a width of ~10 µm and of Mg- and Dy-containing phases. In addition, X-ray diffraction analysis demonstrated that ECAP resulted in the formation of the basal texture in the alloy. These changes in the microstructure and texture lead to an increase in ultimate tensile strength up to 262 ± 7 MPa and ductility up to 5.7 ± 0.2%. ECAP slows down the degradation process, apparently due to the formation of a more homogeneous microstructure. It was found that the alloy degradation rate in vivo after subcutaneous implantation in mice is significantly lower than in vitro ones. ECAP does not impair biocompatibility in vitro and in vivo of the Zn-1%Mg-0.1%Dy alloy. No signs of suppuration, allergic reactions, the formation of visible seals or skin ulcerations were observed after implantation of the alloy. This may indicate the absence of an acute reaction of the animal body to the Zn-1%Mg-0.1%Dy alloy in both states.
研究了等径角挤压（ECAP）后的Zn-1%Mg-0.1%Dy合金的结构、相组成、腐蚀与力学性能，以及体内外生物相容性方面。ECAP后的组织细化导致形成宽度约为10 µm的拉长α-Zn晶粒以及含Mg和Dy的相。此外，X射线衍射分析表明，ECAP导致合金中形成基面织构。微观结构和织构的这些变化使极限抗拉强度提高到262±7 MPa，伸长率提高到5.7±0.2%。ECAP减缓了降解过程，这显然是由于形成了更均匀的微观结构。研究发现，该合金在小鼠皮下植入后的体内降解速率明显低于体外降解速率。ECAP不会损害Zn-1%Mg-0.1%Dy合金的体内外生物相容性。合金植入后未观察到化脓、过敏反应、可见瘢痕形成或皮肤溃疡迹象。这可能表明动物体在两种状态下对Zn-1%Mg-0.1%Dy合金均无急性反应。
