Alhatim Husein, Abdullah Muhammad Nazrul Hakim, Abu Bakar Suhaili, Amer Sayed Amin
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Department of Forensic Sciences, College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh 14812, Saudi Arabia.
Curr Issues Mol Biol. 2023 Sep 4;45(9):7275-7285. doi: 10.3390/cimb45090460.
This review highlights the effect of carcinomas on the results of the examination of autosomal genetic traits for identification and paternity tests when carcinoid tissue is the only source and no other samples are available. In DNA typing or genetic fingerprinting, variable elements are isolated and identified within the base pair sequences that form the DNA. The person's probable identity can be determined by analysing nucleotide sequences in particular regions of DNA unique to everyone. Genetics plays an increasingly important role in the risk stratification and management of carcinoma patients. The available information from previous studies has indicated that in some incidents, including mass disasters and crimes such as terrorist incidents, biological evidence may not be available at the scene of the accident, except for some unknown human remains found in the form of undefined human tissues. If these tissues have cancerous tumours, it may affect the examination of the genetic traits derived from these samples, thereby resulting in a failure to identify the person. Pathology units, more often, verify the identity of the patients who were diagnosed with cancer in reference to their deceased tumorous relatives. Genetic fingerprinting (GF) is also used in paternity testing when the alleged parent disappeared or died and earlier was diagnosed and treated for cancer.
本综述强调了在类癌组织是唯一可用样本且无其他样本的情况下，癌对常染色体遗传特征检测结果用于身份鉴定和亲子鉴定的影响。在DNA分型或基因指纹识别中，会在构成DNA的碱基对序列中分离并鉴定可变元件。通过分析每个人特有的DNA特定区域中的核苷酸序列，可以确定一个人的可能身份。遗传学在癌症患者的风险分层和管理中发挥着越来越重要的作用。以往研究的现有信息表明，在一些事件中，包括大规模灾难和恐怖袭击等犯罪事件，事故现场可能没有生物证据，除了以未明确的人体组织形式发现的一些身份不明的人类遗骸。如果这些组织患有癌性肿瘤，可能会影响对这些样本衍生的遗传特征的检测，从而导致无法识别个体。病理科更常通过参考已故肿瘤亲属来核实被诊断患有癌症的患者的身份。当被指控的父母失踪或死亡且此前曾被诊断患有癌症并接受治疗时，基因指纹识别（GF）也用于亲子鉴定。
