Medical Oncology Department, Ramón y Cajal University Hospital, 28034 Madrid, Spain.
Ramón y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain.
Curr Oncol. 2023 Sep 14;30(9):8426-8433. doi: 10.3390/curroncol30090613.
Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. This is a case report of a 77-year-old Spanish male patient with localized SCC of the colon, who presented a pathological complete response in the surgical specimen after neoadjuvant chemotherapy with cisplatin and etoposide. To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. As clinical guidelines for the management of this entity are lacking, and therefore its management has not been standardized, an attempt to summarize the current evidence in the literature was made.
肺外小细胞癌（SCC）是一种罕见的肿瘤，与肺部 SCC 具有某些共同特征，主要发生在胃肠道（GIT）中。它是一种高级别、低分化的神经内分泌肿瘤，通常在晚期诊断，预后较差，在这种情况下治疗选择有限。这是一例 77 岁西班牙男性患者的病例报告，该患者患有局部结肠 SCC，在接受顺铂和依托泊苷新辅助化疗后，手术标本中出现了病理完全缓解。迄今为止，手术后 5 年，患者仍无肿瘤复发的迹象。由于缺乏针对该实体的临床管理指南，因此其管理尚未标准化，我们尝试总结了目前文献中的证据。
