气道中细菌与……之间的相互作用：从真菌微生物组到分子相互作用（原文中“and”后面内容缺失）

Interactions between Bacteria and in Airways: From the Mycobiome to Molecular Interactions.

作者信息

Debourgogne Anne, Monpierre Lorra, Sy Khadeeja Adam, Valsecchi Isabel, Decousser Jean-Winoc, Botterel Françoise

机构信息

UR 7300, Stress Immunité Pathogène, Université de Lorraine, 54000 Vandoeuvre les Nancy, France.

Unité de Parasitologie-Mycologie, Département de Prévention, Diagnostic et Traitement des Infections, CHU Henri Mondor, Assistance Publique des Hôpitaux de Paris (APHP), 94000 Créteil, France.

出版信息

J Fungi (Basel). 2023 Sep 1;9(9):900. doi: 10.3390/jof9090900.

DOI:10.3390/jof9090900

PMID:37755008

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10533028/

Abstract

Interactions between different kingdoms of microorganisms in humans are common but not well described. A recent analysis of the mycobiome has described the presence of different fungi and their positive and/or negative interactions with bacteria and other fungi. In chronic respiratory diseases, these different microorganisms form mixed biofilms to live inside. The interactions between Gram-negative bacteria and filamentous fungi in these biofilms have attracted more attention recently. In this review, we analyse the microbiota of the respiratory tract of healthy individuals and patients with chronic respiratory disease. Additionally, we describe the regulatory mechanisms that rule the mixed biofilms of and Gram-negative bacteria and the effects of this biofilm on clinical presentations.

摘要

人类体内不同微生物界之间的相互作用很常见，但尚未得到充分描述。最近对真菌微生物群的一项分析描述了不同真菌的存在及其与细菌和其他真菌的正负相互作用。在慢性呼吸道疾病中，这些不同的微生物形成混合生物膜并在其中生存。这些生物膜中革兰氏阴性菌与丝状真菌之间的相互作用最近受到了更多关注。在这篇综述中，我们分析了健康个体和慢性呼吸道疾病患者呼吸道的微生物群。此外，我们描述了调控革兰氏阴性菌和丝状真菌混合生物膜的机制以及这种生物膜对临床表现的影响。