Xavier Melissa Orzechowski, Poester Vanice Rodrigues, Trápaga Mariana Rodrigues, Stevens David A
Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina (FAMED), Universidade Federal do Rio Grande (FURG), Rio Grande 96200-190, RS, Brazil.
Laboratório de Micologia, Faculdade de Medicina (FAMED), Universidade Federal do Rio Grande (FURG), Rio Grande 96200-190, RS, Brazil.
J Fungi (Basel). 2023 Sep 13;9(9):921. doi: 10.3390/jof9090921.
Sporotrichosis caused by is an emergent mycosis that is now a worldwide concern. One important step to sporotrichosis control is its correct treatment. However, limitations abound; thus, new antifungals, mainly focused on , are urgently needed. We performed a systematic review (following the PRISMA guideline) focused on (1) the global distribution of human and animal sporotrichosis by , especially outside of Brazil; (2) appraising therapies tested against this pathogen. We identified sporotrichosis caused by reported in five countries (Paraguay, Chile, Argentina, the United Kingdom, and the United States) in addition to Brazil, occurring on three continents, highlighting the epidemiological scenario in Argentina with an important increase in reported cases in recent years. Regarding the antifungal activity of drugs, 25 articles described the in vitro action of 20 unique chemicals and eight repurposed drugs against . Only five studies reported in vivo activity against (five drugs) using invertebrate and vertebrate models. Sporotrichosis caused by has a global impact and it is no longer specifically a Brazilian problem. We review the need for understanding the disease epidemiology, education of clinicians and of the populace, organization of health care delivery to respond to a spreading epidemic, and research on therapy for sporotrichosis.
由[病原体名称未给出]引起的孢子丝菌病是一种新出现的真菌病，现已成为全球关注的问题。控制孢子丝菌病的一个重要步骤是正确治疗。然而，存在诸多限制；因此，迫切需要主要针对[相关内容未明确]的新型抗真菌药物。我们进行了一项系统综述（遵循PRISMA指南），重点关注：（1）按[相关因素未明确]划分的人类和动物孢子丝菌病的全球分布情况，特别是在巴西以外地区；（2）评估针对该病原体进行测试的疗法。我们发现，除巴西外，在五个国家（巴拉圭、智利、阿根廷、英国和美国）报告了由[病原体名称未给出]引起的孢子丝菌病，该病发生在三大洲，突出了阿根廷的流行病学情况，近年来报告病例有显著增加。关于药物的抗真菌活性，25篇文章描述了20种独特化学物质和8种重新利用药物对[病原体名称未给出]的体外作用。只有五项研究报告了使用无脊椎动物和脊椎动物模型对[病原体名称未给出]（五种药物）的体内活性。由[病原体名称未给出]引起的孢子丝菌病具有全球影响，它不再只是巴西特有的问题。我们审视了了解疾病流行病学、对临床医生和民众进行教育、组织医疗服务以应对不断蔓延的疫情以及对孢子丝菌病治疗进行研究的必要性。
