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一名患有隐球菌性脑膜炎的艾滋病患者的感染情况。

Infection in an AIDS Patient with Cryptococcal Meningitis.

作者信息

Wang Li-An, Chuang Yu-Chuan, Yeh Ting-Kuang, Lin Kuan-Pei, Lin Chi-Jan, Liu Po-Yu

机构信息

Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

出版信息

J Fungi (Basel). 2023 Sep 15;9(9):932. doi: 10.3390/jof9090932.

Abstract

Concurrent infections caused by multiple fungal pathogens in immunocompromised patients can pose diagnostic and treatment challenges. Here, we presented the first reported case in Taiwan of an AIDS patient who had concurrent infection with meningitis and lymphadenopathy. The patient presented with an enlarged inguinal lymph node and was diagnosed with lymphadenitis. The species was identified using DNA sequencing, which had the capability of differentiating it from other species. The patient was discharged from the hospital following treatment with amphotericin B and subsequent administration of voriconazole. This case highlights the importance of maintaining a suspicion of co-infections and utilizing appropriate diagnostic tools, such as DNA sequencing, to identify possible pathogens. Further studies are needed to determine the optimal treatment for and other co-infecting fungal pathogens.

摘要

免疫功能低下患者由多种真菌病原体引起的并发感染可能带来诊断和治疗挑战。在此,我们报告了台湾首例艾滋病患者同时感染脑膜炎和淋巴结病的病例。该患者腹股沟淋巴结肿大,被诊断为淋巴结炎。通过DNA测序鉴定该菌种,其能够将该菌种与其他菌种区分开来。患者接受两性霉素B治疗及随后的伏立康唑给药后出院。该病例凸显了对合并感染保持怀疑并利用适当诊断工具(如DNA测序)来识别可能病原体的重要性。需要进一步研究以确定该菌种及其他合并感染真菌病原体的最佳治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffca/10532648/b07b567d3151/jof-09-00932-g001.jpg

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