Spekker Eleonóra, Nagy-Grócz Gábor
Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Department of Neurology, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, Hungary.
Neurol Int. 2023 Sep 13;15(3):1174-1190. doi: 10.3390/neurolint15030073.
Migraine, a prevalent neurological condition and the third most common disease globally, places a significant economic burden on society. Despite extensive research efforts, the precise underlying mechanism of the disease remains incompletely comprehended. Nevertheless, it is established that the activation and sensitization of the trigeminal system are crucial during migraine attacks, and specific substances have been recognized for their distinct involvement in the pathomechanism of migraine. Recently, an expanding body of data indicates that migraine attacks can be prevented and treated through dietary means. It is important to highlight that the various diets available pose risks for patients without professional guidance. This comprehensive overview explores the connection between migraine, the gut microbiome, and gastrointestinal disorders. It provides insight into migraine-triggering foods, and discusses potential diets to help reduce the frequency and severity of migraine attacks. Additionally, it delves into the benefits of using pre- and probiotics as adjunctive therapy in migraine treatment.
偏头痛是一种常见的神经系统疾病，也是全球第三大常见疾病，给社会带来了巨大的经济负担。尽管进行了广泛的研究，但该疾病的确切潜在机制仍未完全明了。然而，已确定三叉神经系统的激活和敏化在偏头痛发作期间至关重要，并且特定物质因其在偏头痛发病机制中的不同作用而被识别。最近，越来越多的数据表明偏头痛发作可以通过饮食手段进行预防和治疗。需要强调的是，在没有专业指导的情况下，各种可用的饮食对患者都有风险。本综述探讨了偏头痛、肠道微生物群和胃肠道疾病之间的联系。它深入研究了引发偏头痛的食物，并讨论了有助于减少偏头痛发作频率和严重程度的潜在饮食。此外，还深入探讨了使用益生元和益生菌作为偏头痛治疗辅助疗法的益处。
