Kappéter Ágnes, Sipos Dávid, Varga Adorján, Vigvári Szabolcs, Halda-Kiss Bernadett, Péterfi Zoltán
1st Department of Internal Medicine, Department of Infectology, University of Pecs Clinical Centre, H7623 Pécs, Hungary.
Department of Medical Microbiology and Immunology, University of Pecs Clinical Centre, H7624 Pécs, Hungary.
Microorganisms. 2023 Aug 14;11(8):2083. doi: 10.3390/microorganisms11082083.
Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and persists as a result of earlier antibiotic therapy, changes the composition of the intestinal flora, and can lead to the development of various diseases such as metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Metabolites produced by the gut microbiome have been shown to influence the gut-brain axis. The use of probiotics as a dietary supplement may reduce the number and severity of migraine episodes. Dietary strategies can affect the course of migraines and are a valuable tool for improving migraine management. With fecal microbiota transplantation, gut microbial restoration is more effective and more durable. Changes after fecal microbiota transplantation were studied in detail, and many data help us to interpret the successful interventions. The microbiological alteration of the gut microflora can lead to normalization of the inflammatory mediators, the serotonin pathway, and influence the frequency and intensity of migraine pain.
偏头痛是一种疼痛性神经系统疾病，其特征是头部一侧或双侧出现剧痛。它可能与肠道微生物群的变化有关，而肠道微生物群会受到抗生素使用及其他因素的影响。由于早期抗生素治疗而产生并持续存在的生态失调会改变肠道菌群的组成，并可能导致各种疾病的发生，如代谢紊乱、肥胖、血液系统恶性肿瘤、神经或行为障碍以及偏头痛。肠道微生物群产生的代谢产物已被证明会影响肠-脑轴。使用益生菌作为膳食补充剂可能会减少偏头痛发作的次数和严重程度。饮食策略会影响偏头痛的病程，是改善偏头痛管理的一项重要手段。通过粪便微生物群移植，肠道微生物的恢复更有效且更持久。对粪便微生物群移植后的变化进行了详细研究，许多数据有助于我们解读这些成功的干预措施。肠道微生物群的微生物学改变可导致炎症介质、血清素途径正常化，并影响偏头痛疼痛的频率和强度。
