咖啡、腺苷和肝脏。
Coffee, adenosine, and the liver.
机构信息
Yale University School of Medicine and VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT, 06515, USA.
出版信息
Purinergic Signal. 2024 Feb;20(1):21-28. doi: 10.1007/s11302-023-09968-5. Epub 2023 Sep 27.
Abstract
A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic liver disease. The primary pharmacologic role of caffeine is to act as an inhibitor of adenosine receptors. Because key liver cells express adenosine receptors linked to liver injury, regeneration, and fibrosis, it is plausible that the biological effects of coffee are explained by effects of caffeine on adenosinergic signaling in the liver. This review is designed to help the reader make sense of that hypothesis, highlighting key observations in the literature that support or dispute it.
摘要
多项观察性研究表明，咖啡（可能通过咖啡因起作用）可改善慢性肝病患者的健康结局。咖啡因的主要药理作用是作为腺苷受体抑制剂。由于关键的肝细胞表达与肝损伤、再生和纤维化相关的腺苷受体，因此咖啡的生物学效应可以通过咖啡因对肝脏中腺苷能信号的作用来解释，这是合理的。本综述旨在帮助读者理解这一假说，重点强调支持或反驳该假说的文献中的关键观察结果。
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3
Hepatic inflammatory responses in liver fibrosis.
Nat Rev Gastroenterol Hepatol. 2023 Oct;20(10):633-646. doi: 10.1038/s41575-023-00807-x. Epub 2023 Jul 3.
4
Coffee, Green Tea Intake, and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies.
Nutr Cancer. 2023;75(5):1295-1308. doi: 10.1080/01635581.2023.2178949. Epub 2023 Apr 10.
5
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Am J Physiol Gastrointest Liver Physiol. 2023 Jun 1;324(6):G419-G421. doi: 10.1152/ajpgi.00026.2023. Epub 2023 Mar 28.
6
Global Epidemiology and Genetics of Hepatocellular Carcinoma.
Gastroenterology. 2023 Apr;164(5):766-782. doi: 10.1053/j.gastro.2023.01.033. Epub 2023 Feb 2.
7
The evolving role of liver sinusoidal endothelial cells in liver health and disease.
Hepatology. 2023 Aug 1;78(2):649-669. doi: 10.1097/HEP.0000000000000207. Epub 2023 Jan 3.
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10
Association of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Coffee Consumption With All-Cause and Cause-Specific Mortality : A Large Prospective Cohort Study.
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