Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
University of Ulsan, College of Medicine, Seoul, Korea.
Toxicol Pathol. 2022 Jul;50(5):628-637. doi: 10.1177/01926233221095449. Epub 2022 May 10.
Marmosets are becoming more utilized in biomedical research due to multiple advantages including (1) a nonhuman primate of a smaller size with less cost for housing, (2) physiologic similarities to humans, (3) translatable hepatic metabolism, (4) higher numbers of litters per year, (5) genome is sequenced, molecular reagents are available, (6) immunologically similar to humans, (7) transgenic marmosets with germline transmission have been produced, and (8) are naturally occurring hematopoietic chimeras. With more use of marmosets, disease surveillance over a wide range of ages of marmosets has been performed. This has led to a better understanding of the disease management of spontaneous diseases that can occur in colonies. Knowledge of clinical signs and histologic lesions can assist in maximizing the colony's health, allowing for improved outcomes in translational studies within biomedical research. Here, we describe some basic husbandry, biology, common spontaneous diseases, and animal model applications for the common marmoset in biomedical research.
由于多种优势，包括（1）体型较小、住房成本较低的非人类灵长类动物，（2）与人类生理相似，（3）可转化的肝代谢，（4）每年产仔数量更多，（5）基因组测序，分子试剂可用，（6）免疫上与人类相似，（7）已产生具有种系传递的转基因狨猴，以及（8）是天然存在的造血嵌合体，狨猴在生物医学研究中越来越多地被用于生物医学研究。随着狨猴的更多使用，对狨猴广泛年龄段的疾病监测已经进行。这导致对可以在群体中发生的自发性疾病的疾病管理有了更好的理解。对临床症状和组织学病变的了解有助于最大限度地提高群体的健康水平，从而改善生物医学研究中的转化研究结果。在这里，我们描述了一些在生物医学研究中常见的狨猴的基本饲养、生物学、常见自发性疾病和动物模型应用。
