[类风湿关节炎的流行病学概况]

[Epidemiological profile of rheumatoid arthritis].

作者信息

Miguel-Lavariega Deyanira, Elizararrás-Rivas Jesús, Villarreal-Ríos Enrique, Baltiérrez-Hoyos Rafael, Velasco-Tobón Ulises, Vargas-Daza Emma Rosa, Galicia-Rodríguez Liliana

机构信息

Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 65, Servicio de Medicina Familiar. Oaxaca, Oaxaca, México.

Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Oaxaca, Coordinación Auxiliar Médica de Investigación en Salud. Oaxaca, Oaxaca, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2023 Sep 4;61(5):574-582. doi: 10.5281/zenodo.8316427.

DOI:10.5281/zenodo.8316427

PMID:37757464

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10599789/

Abstract

BACKGROUND

Rheumatoid arthritis affects approximately between 0.3 and 1.2% of the world population. In Latin America, different studies have estimated a prevalence between 0.2 and 0.5% in the population over 16 years of age.

OBJECTIVE

To identify the epidemiological profile of rheumatoid arthritis.

MATERIAL AND METHODS

Descriptive cross-sectional design carried out in an urban population of a social security institution in Mexico. The information of the clinical file of 373 patients was studied. The epidemiological profile included the sociodemographic dimension, family history, health, clinical, therapeutic, biochemical, extra-articular manifestations and complications. Statistical analysis percentages, means, confidence intervals for percentages and confidence intervals for averages were calculated.

RESULTS

The wrists were the most affected joints with 44.6% (95% CI: 39.5-49.6%). The extra-articular manifestation with the highest prevalence was asthenia with 9.9% (95% CI: 6.9-12.9%); predominant diagnosis according to ICD-10 was seropositive rheumatoid arthritis with 59.8% (95% CI: 54.8-64.8%), and the rheumatoid factor was highly positive in 78.3% (95% CI: 74.1-82.5%); predominant treatment was with combined therapy at diagnosis in 97.6% (95% CI: 96.0-99.1%). The duration of treatment was > 10 years in 34.1% (95% CI: 29.2-38.8%).

CONCLUSION

This work has described the epidemiological profile of the patient with rheumatoid arthritis in different dimensions.

摘要

背景

类风湿关节炎影响着全球约0.3%至1.2%的人口。在拉丁美洲，不同研究估计16岁以上人群的患病率在0.2%至0.5%之间。

目的

确定类风湿关节炎的流行病学特征。

材料与方法

在墨西哥一家社会保障机构的城市人口中进行描述性横断面设计。研究了373例患者的临床档案信息。流行病学特征包括社会人口学维度、家族史、健康状况、临床情况、治疗情况、生化指标、关节外表现及并发症。计算了统计分析中的百分比、均值、百分比的置信区间和均值的置信区间。

结果

手腕是最常受累的关节，占44.6%（95%置信区间：39.5 - 49.6%）。患病率最高的关节外表现是乏力，为9.9%（95%置信区间：6.9 - 12.9%）；根据国际疾病分类第10版（ICD - 10）的主要诊断是血清阳性类风湿关节炎，占59.8%（95%置信区间：54.8 - 64.8%），类风湿因子高度阳性的比例为78.3%（95%置信区间：74.1 - 82.5%）；主要治疗方式是诊断时联合治疗，占97.6%（95%置信区间：96.0 - 99.1%）。治疗时间超过10年的患者占34.1%（95%置信区间：29.2 - 38.8%）。