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哥伦比亚的类风湿关节炎:一项全国性登记研究的临床特征和流行率。

Rheumatoid arthritis in Colombia: a clinical profile and prevalence from a national registry.

机构信息

High-Cost Disease Fund, Bogotá D.C., Colombia.

University Hospital Fundación Santa Fe de Bogotá, Universidad El Bosque, Bogotá D.C., Colombia.

出版信息

Clin Rheumatol. 2021 Sep;40(9):3565-3573. doi: 10.1007/s10067-021-05710-x. Epub 2021 Mar 27.

Abstract

BACKGROUND

There is a need to describe the demographic and clinical characteristics of people diagnosed with rheumatoid arthritis who are attended within the Colombian health system. This characterization allows prioritizing populations with specific risks, programming the use of health services, and planning the costs necessary to guarantee equitable care.

OBJECTIVE

To assess the demographic and clinical characteristics of a cohort of patients with rheumatoid arthritis using national data collected by the High-Cost Disease Fund (CAC in Spanish).

METHODS

A cross-sectional study from a secondary source. Data was gathered from a national administrative registry. A descriptive analysis was performed on sociodemographic and clinical characteristics. Age-standardized prevalence was estimated at national level and by geographical regions. Remission rates were also estimated for Colombian departments and regions.

RESULTS

By 2019, 81,386 patients with rheumatoid arthritis were reported in Colombia. The relation female-male was 5.2:1. The median age was 59 years (IQR: 50-67). Prevalence was higher in people aged 50-69 years. The most frequent comorbidities were high blood pressure (31.15%) and osteoporosis (19.46%). Age-standardized prevalence of rheumatoid arthritis was 0.24 per 100 population (95% CI: 0.23-0.24). In cases with complete information, 57.57% of departments had remission rates up to 30%.

CONCLUSION

Rheumatoid arthritis in Colombia was more frequent in females aged ≥50 year. Age-standardized prevalence was lower than reported by other studies performed in Colombia but similar to the estimated internationally for the country. Key Points • More than 80,000 rheumatoid arthritis patients were reported to this national registry in Colombia in 2019, finding an age-standardized prevalence of 0.24 per 100 population. • Hypertension was the most common comorbidity reported in people with rheumatoid arthritis. This finding is similar to the reports by similar studies such as the COMORA. • A major strength of this study is the large sample size since data come from a nationwide registry of people with rheumatoid arthritis, supported by the National Ministry of Health. Additionally, this registry has a rigorous data monitoring process that guarantees the internal validity of data and provides valuable information for decision-making based on local evidence. • Prevalence of rheumatoid arthritis was higher in females between 50 and 65 years. Age-standardized prevalence was lower than previously reported in Colombia, but similar to the world estimations.

摘要

背景

需要描述在哥伦比亚卫生系统就诊的类风湿关节炎患者的人口统计学和临床特征。这种特征描述有助于确定具有特定风险的人群,规划卫生服务的使用,并计划为确保公平护理所需的费用。

目的

使用高成本疾病基金(CAC)收集的国家数据评估类风湿关节炎患者队列的人口统计学和临床特征。

方法

这是一项二次来源的横断面研究。数据来自国家行政登记处。对社会人口统计学和临床特征进行描述性分析。在全国范围内和按地理区域估计年龄标准化患病率。还估计了哥伦比亚各省和地区的缓解率。

结果

截至 2019 年,哥伦比亚报告了 81386 例类风湿关节炎患者。男女比例为 5.2:1。中位年龄为 59 岁(IQR:50-67)。50-69 岁人群的患病率较高。最常见的合并症是高血压(31.15%)和骨质疏松症(19.46%)。年龄标准化的类风湿关节炎患病率为每 100 人 0.24 例(95%CI:0.23-0.24)。在信息完整的病例中,57.57%的省份缓解率达到 30%。

结论

哥伦比亚的类风湿关节炎在≥50 岁的女性中更为常见。年龄标准化患病率低于哥伦比亚其他研究报告,但与国际上对该国的估计相似。

关键点

• 2019 年,哥伦比亚国家登记处报告了超过 80,000 例类风湿关节炎患者,发现年龄标准化患病率为每 100 人 0.24 例。

• 高血压是类风湿关节炎患者报告的最常见合并症。这一发现与 COMORA 等类似研究的报告相似。

• 这项研究的一个主要优势是样本量大,因为数据来自全国性的类风湿关节炎患者登记处,由国家卫生部支持。此外,该登记处有严格的数据监测流程,保证了数据的内部有效性,并提供了基于当地证据的决策的有价值信息。

• 类风湿关节炎在 50-65 岁的女性中更为常见。年龄标准化患病率低于哥伦比亚之前的报告,但与世界估计值相似。

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