Takahashi H, Hanano M, Hayashi S, Arai Y, Yoshino N, Takakuwa E, Tatewaki W, Nagayama R, Takizawa S, Shibata A
Tohoku J Exp Med. 1986 Aug;149(4):351-7. doi: 10.1620/tjem.149.351.
Plasma levels of protein C (PC) and vitamin K-dependent coagulation factors (factors II, VII, IX and X) were measured in 100 specimens from patients on long-term warfarin therapy. Both activities and antigens of these coagulation factors were decreased, depending on the thrombotest values. Factor II activity/antigen ratio and factor X activity/antigen ratio were correlated well with thrombotest values, indicating that the concentration of inactive molecules (PIVKAs) relative to normal proteins increases with increasing intensity of anticoagulation. Although PC antigen (PC:Ag) was also decreased, the ratios between PC:Ag and vitamin K-dependent coagulation factor antigens remained constant, being independent of the intensity of warfarin therapy. These findings indicate that long-term oral anticoagulant therapy results in the suppression of the synthesis of both vitamin K-dependent coagulation factors and PC, but the production of the coagulant and anticoagulant proteins is well-balanced.
在100例接受长期华法林治疗患者的样本中检测了蛋白C（PC）以及维生素K依赖的凝血因子（凝血因子II、VII、IX和X）的血浆水平。这些凝血因子的活性和抗原均降低，这取决于凝血酶试验值。凝血因子II活性/抗原比值和凝血因子X活性/抗原比值与凝血酶试验值密切相关，表明相对于正常蛋白，无活性分子（PIVKAs）的浓度随着抗凝强度的增加而升高。尽管PC抗原（PC:Ag）也降低，但PC:Ag与维生素K依赖的凝血因子抗原之间的比值保持恒定，与华法林治疗强度无关。这些发现表明，长期口服抗凝治疗会抑制维生素K依赖的凝血因子和PC的合成，但促凝蛋白和抗凝蛋白的产生保持良好平衡。
