Sasaki I, Naito H, Matsuno S, Sato T
Tohoku J Exp Med. 1986 Sep;150(1):91-9. doi: 10.1620/tjem.150.91.
The influence of simultaneous ligation of the bile and pancreatic ducts on gastric acid secretion and gut hormones, particularly gastrin and secretin, was studied in 5 dogs with a Heidenhain pouch. In addition, the pH of the duodenal content was measured in 2 dogs with a duodenal fistula. Tests in response to a test meal were done during the control and observation periods. In all of the 5 dogs the mean 24 hr-acid output from the Heindenhain pouches showed a significant increase from 199 to 564%. Plasma gastrin levels during the fasting showed no significant change, but the peak response to the test meal significantly decreased from 83.6 +/- 4.4 pg/ml (mean +/- S.E.) before the ligation to 42.1 +/- 4.2 pg/ml after the ligation. Plasma secretin levels were significantly elevated after the ligation both during fasting and after the test meal. The pH of the duodenal contents after the test meal was lower after the ligation than before. These results suggest that gastric hypersecretion induced by the simultaneous ligation of the common bile and pancreatic ducts is not related simply to release of gastrin, and further hypersercretinemia may depend on gastric hypersecretion.
在5只装有海登海因小胃的狗身上，研究了同时结扎胆管和胰管对胃酸分泌以及肠道激素，尤其是胃泌素和促胰液素的影响。此外，在2只患有十二指肠瘘的狗身上测量了十二指肠内容物的pH值。在对照期和观察期内进行了对试餐的反应测试。在所有5只狗中，海登海因小胃的平均24小时酸分泌量从199%显著增加到564%。空腹时血浆胃泌素水平无显著变化，但对试餐的峰值反应从结扎前的83.6±4.4 pg/ml（平均值±标准误）显著降至结扎后的42.1±4.2 pg/ml。结扎后，空腹时和试餐后血浆促胰液素水平均显著升高。结扎后试餐时十二指肠内容物的pH值低于结扎前。这些结果表明，同时结扎胆总管和胰管所诱导的胃酸分泌过多并非简单地与胃泌素释放有关，进一步的高促胰液素血症可能依赖于胃酸分泌过多。
