Sekine T, Kameyama J, Sasaki I, Lin J, Sato T
Tohoku J Exp Med. 1981 May;134(1):29-38. doi: 10.1620/tjem.134.29.
The influence of pancreatic duct ligation (PDL) on gastric secretion was investigated in dogs with a Heidenhain pouch. A test meal was given to the dogs before PDL, and following PDL the dogs were administered with the test meal mixed with pancreatic enzymes and with the test meal alone in succession. The responses to the test meal were examined in the control period and every one week for a period of 1 to 6 weeks following PDL to identify the changes in gastric acid secretion, serum gastrin levels, immunoreactive glucagon (IRG) levels and immunoreactive insulin (IRI) levels. Gastric acid secretion in response to food stimulations markedly increased after PDL. However, the acid secretion was significantly inhibited by the administration of pancreatic enzymes. Serum gastrin levels began to increase from the second week and continued to increase until the sixth week after PDL, revealing no effect of pancreatic enzymes. IRG levels also increased following PDL, particularly in cases administered with pancreatic enzymes. IRI levels were higher at the first week of PDL than before PDL, but tended to decrease thereafter. It is assumed that gastric hypersecretion after PDL would have complicated relations with IRG, gastric inhibitory polypeptide (GIP) as well as with antral gastrin.
在具有海登海因小胃的犬中研究了胰管结扎术（PDL）对胃液分泌的影响。在进行PDL之前给犬喂食试验餐，在PDL之后，依次给犬喂食混合有胰酶的试验餐和单独的试验餐。在对照期以及PDL后1至6周内每周检查一次对试验餐的反应，以确定胃酸分泌、血清胃泌素水平、免疫反应性胰高血糖素（IRG）水平和免疫反应性胰岛素（IRI）水平的变化。PDL后，对食物刺激的胃酸分泌明显增加。然而，胰酶的给药显著抑制了胃酸分泌。血清胃泌素水平从第二周开始升高，并持续升高至PDL后的第六周，表明胰酶无作用。PDL后IRG水平也升高，特别是在给予胰酶的情况下。IRI水平在PDL的第一周高于PDL前，但此后趋于下降。据推测，PDL后的胃酸分泌过多可能与IRG、胃抑制性多肽（GIP）以及胃窦胃泌素存在复杂的关系。
