从红树林内生真菌Didymella sp. CYSK-4中分离得到的代谢产物及其细胞毒性活性。
Metabolites isolated from the mangrove endophytic fungus Didymella sp. CYSK-4 and their cytotoxic activities.
作者信息
Yuan Yilin, Wang Guisheng, She Zhigang, Chen Yan, Kang Wenyi
机构信息
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China; School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
出版信息
Fitoterapia. 2023 Dec;171:105692. doi: 10.1016/j.fitote.2023.105692. Epub 2023 Sep 26.
Two new 12- or 13- membered-ring macrocyclic alkaloids ascomylactam D and E (1 & 2), and a pair of new enantiomer (+)- and (-)- didymetone (3) were purified from the mangrove endophytic fungus Didymella sp. CYSK-4. Their structures and absolute configurations were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, ECD and C NMR calculations. Compound 2 exhibited significant cytotoxicity against human A549 and KYSE 150 cancer cell lines with IC values of 2.8 μM and 5.9 μM, respectively.
从红树林内生真菌Didymella sp. CYSK-4中分离得到两个新的12或13元环大环生物碱曲霉内酰胺D和E（1和2），以及一对新的对映体（+）-和（-）-双隔孢菌酮（3）。通过广泛的光谱分析、单晶X射线衍射、电子圆二色光谱（ECD）和碳核磁共振（C NMR）计算确定了它们的结构和绝对构型。化合物2对人A549和KYSE 150癌细胞系表现出显著的细胞毒性，其半数抑制浓度（IC）值分别为2.8 μM和5.9 μM。
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