College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China.
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
J Asian Nat Prod Res. 2024 Aug;26(8):993-1000. doi: 10.1080/10286020.2024.2335254. Epub 2024 Apr 17.
A new 14-membered resorcylic acid lactone (RAL), chaetolactone A (), along with three known ones (-), was obtained from the fermentation of the soil-derived fungus SSJZ001. Their structures were established based on extensive spectroscopic data analyses (UV, IR, HRESIMS, 1D, and 2D NMR),C NMR chemical shifts calculations coupled with the DP4 probability method, theoretical calculations of ECD spectra, as well as X-ray diffraction analysis. All compounds were evaluated for their cytotoxic effects against A549, HO-8910, and MCF-7 cell lines.
从土壤来源真菌 SSJZ001 的发酵产物中分离得到了一个新的 14 元环的雷琐酚酸内酯（RAL）化合物 chaetolactone A（），以及三个已知化合物（-）。基于广泛的光谱数据分析（UV、IR、HRESIMS、1D 和 2D NMR）、¹³C NMR 化学位移计算与 DP4 概率方法相结合、ECD 光谱的理论计算以及 X 射线衍射分析，确定了它们的结构。所有化合物都进行了 A549、HO-8910 和 MCF-7 细胞系的细胞毒性评价。
