Heo Kevin Y, Bonsu Janice M, Muffly Brian T, Rieger Elizabeth, Song Joseph, Ayeni Ayomide M, Guild George N, Premkumar Ajay
Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia.
J Arthroplasty. 2024 Mar;39(3):766-771.e2. doi: 10.1016/j.arth.2023.09.028. Epub 2023 Sep 25.
The COVID-19 pandemic introduced a new set of challenges for the arthroplasty community, including the management of patients diagnosed with COVID-19 following revision total knee arthroplasty (rTKA) and its potential impact on postoperative recovery. This study sought to characterize the risks of postoperative COVID-19 infection among rTKA patients.
A large national database was utilized to query 8,022 total patients who underwent rTKA between 2018 and 2021, of which 60 had a COVID diagnosis within 90 days after surgery (rTKA/COVID positive). These patients were 1:10 propensity-score matched to 600 rTKA patients who did not have a 90-day postoperative COVID diagnosis (rTKA/COVID negative) and 600 COVID positive patients who did not undergo rTKA. Controlling for potential confounders, multivariate logistic regressions were utilized to compare 90-day postoperative complications between groups.
Compared to rTKA/COVID negativepatients, the rTKA/COVID positive cohort had significantly higher rates of pneumonia (odds ratio [OR] = 6.1, P < .001), pulmonary embolism (PE) (OR = 32.4, P < .001), deep venous thrombosis (DVT) (OR = 32.4, P < .001), and 90-day readmissions (OR = 2.1, P = .02). Similarly, the rTKA/COVID positive cohort had significantly higher rates of pneumonia (OR = 4.3, P = .001), PE (OR = 36.8, P < .001), and DVT (OR = 36.8, P < .001) compared to COVID positive patients who did not undergo rTKA.
Revision total knee arthroplasty patients diagnosed with COVID-19 postoperatively had increased rates of thromboembolic events, pneumoniae, and 90-day readmissions. Risk mitigation efforts would suggest extending the prophylactic anticoagulation period for rTKA patients diagnosed with postoperative COVID-19.
新冠疫情给关节置换领域带来了一系列新挑战,包括对全膝关节置换翻修术(rTKA)后确诊感染新冠病毒的患者的管理及其对术后恢复的潜在影响。本研究旨在描述rTKA患者术后感染新冠病毒的风险。
利用一个大型国家数据库查询了2018年至2021年间接受rTKA的8022例患者,其中60例在术后90天内确诊感染新冠病毒(rTKA/新冠阳性)。这些患者与600例术后90天内未确诊感染新冠病毒的rTKA患者(rTKA/新冠阴性)以及600例未接受rTKA的新冠阳性患者按1:10的倾向评分进行匹配。在控制潜在混杂因素的情况下,采用多因素逻辑回归比较各组术后90天的并发症情况。
与rTKA/新冠阴性患者相比,rTKA/新冠阳性队列的肺炎发生率(比值比[OR]=6.1,P<.001)、肺栓塞(PE)发生率(OR=32.4,P<.001)、深静脉血栓形成(DVT)发生率(OR=32.4,P<.001)和90天再入院率(OR=2.1,P=.02)显著更高。同样,与未接受rTKA的新冠阳性患者相比,rTKA/新冠阳性队列的肺炎发生率(OR=4.3,P=.001)、PE发生率(OR=36.8,P<.001)和DVT发生率(OR=36.8,P<.001)显著更高。
术后确诊感染新冠病毒的全膝关节置换翻修术患者发生血栓栓塞事件、肺炎和90天再入院的几率增加。降低风险的措施建议延长对术后确诊感染新冠病毒的rTKA患者的预防性抗凝时间。