Orme I M, Collins F M
Tubercle. 1986 Jun;67(2):133-40. doi: 10.1016/0041-3879(86)90007-3.
The course of infection with Mycobacterium bovis BCG Pasteur was followed against time in groups of mice vaccinated by either the aerogenic or subcutaneous route. The generation of acquired protective immunity and immunological memory was determined in each group by adoptive immunisation procedures. In addition, subcutaneously vaccinated mice were tested for their ability to resist an aerogenic challenge with a lethal dose of M. tuberculosis. No overall qualitative differences in the magnitude or longevity of antituberculosis immunity in mice vaccinated by the two procedures were observed. It is concluded that aerogenic vaccination offers no immunological advantage over vaccination by the subcutaneous route.
对通过气溶胶或皮下途径接种疫苗的小鼠组，跟踪了牛分枝杆菌卡介苗巴斯德株感染的病程随时间的变化。通过过继免疫程序确定每组中获得性保护性免疫和免疫记忆的产生。此外，对皮下接种疫苗的小鼠进行测试，以检测它们抵抗致死剂量结核分枝杆菌气溶胶攻击的能力。未观察到通过这两种程序接种疫苗的小鼠在抗结核免疫的强度或持久性方面存在总体质量差异。得出的结论是，气溶胶接种与皮下接种相比没有免疫优势。
