Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Division of Nephrology, Department of Medicine, University Health Network, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Nat Commun. 2023 Sep 27;14(1):6041. doi: 10.1038/s41467-023-41678-9.
Neutralization of Omicron subvariants by different bivalent vaccines has not been well evaluated. This study characterizes neutralization against Omicron subvariants in 98 individuals on dialysis or with a kidney transplant receiving the BNT162b2 (BA.4/BA.5) or mRNA-1273 (BA.1) bivalent COVID-19 vaccine. Neutralization against Omicron BA.1, BA.5, BQ.1.1, and XBB.1.5 increased by 8-fold one month following bivalent vaccination. In comparison to wild-type (D614G), neutralizing antibodies against Omicron-specific variants were 7.3-fold lower against BA.1, 8.3-fold lower against BA.5, 45.8-fold lower against BQ.1.1, and 48.2-fold lower against XBB.1.5. Viral neutralization was not significantly different by bivalent vaccine type for wild-type (D614G) (P = 0.48), BA.1 (P = 0.21), BA.5 (P = 0.07), BQ.1.1 (P = 0.10), nor XBB.1.5 (P = 0.10). Hybrid immunity conferred higher neutralizing antibodies against all Omicron subvariants. This study provides evidence that BNT162b2 (BA.4/BA.5) and mRNA-1273 (BA.1) induce similar neutralization against Omicron subvariants, even when antigenically divergent from the circulating variant.
针对不同二价疫苗对奥密克戎亚变体的中和作用尚未得到很好的评估。本研究在 98 名接受 BNT162b2（BA.4/BA.5）或 mRNA-1273（BA.1）二价 COVID-19 疫苗的透析或肾移植患者中，对奥密克戎亚变体的中和作用进行了特征描述。二价疫苗接种一个月后，针对奥密克戎 BA.1、BA.5、BQ.1.1 和 XBB.1.5 的中和作用增加了 8 倍。与野生型（D614G）相比，针对奥密克戎特异性变体的中和抗体对 BA.1 的活性降低了 7.3 倍，对 BA.5 的活性降低了 8.3 倍，对 BQ.1.1 的活性降低了 45.8 倍，对 XBB.1.5 的活性降低了 48.2 倍。针对野生型（D614G）（P=0.48）、BA.1（P=0.21）、BA.5（P=0.07）、BQ.1.1（P=0.10）和 XBB.1.5（P=0.10），二价疫苗类型对病毒中和作用没有显著差异。混合免疫对所有奥密克戎亚变体赋予了更高的中和抗体。本研究提供了证据，表明 BNT162b2（BA.4/BA.5）和 mRNA-1273（BA.1）诱导对奥密克戎亚变体的相似中和作用，即使与循环变体在抗原上存在差异。
