Winearls C G, Fabre J W, Millard P R, Morris P J
Transplantation. 1979 Jul;28(1):36-9. doi: 10.1097/00007890-197907000-00008.
Whole antiserum, IgG, and a greater than 99% pure F(ab')2 preparation were compared for their ability to enhance Lewis renal allografts in DA recipients. Despite having unimpaired antigen-binding capacity, the DA anti-Lewis F(ab')2 was virtually ineffective at the highest dose tested, and was calculated to be a minimum of 100 times less effective than whole antibody. The administration of a 10-fold excess of F(ab')2 before an effective dose of IgG did not block the enhancing effect of the latter.
比较了全抗血清、IgG和纯度大于99%的F(ab')2制剂增强DA受体中Lewis肾同种异体移植的能力。尽管DA抗Lewis F(ab')2的抗原结合能力未受损，但在测试的最高剂量下实际上无效，经计算其效力比全抗体至少低100倍。在有效剂量的IgG之前给予10倍过量的F(ab')2并不阻断后者的增强作用。
