Amin Jay, Gee Claire, Stowell Kiran, Coulthard Daisy, Boche Delphine
Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
Memory Assessment and Research Centre, Tom Rudd Unit, Moorgreen Hospital, Southern Health NHS Foundation Trust, Southampton SO30 3JB, UK.
Cells. 2023 Sep 15;12(18):2283. doi: 10.3390/cells12182283.
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia. People with DLB have an inferior prognosis compared to Alzheimer's disease (AD), but the diseases overlap in their neuropathology and clinical syndrome. It is imperative that we enhance our understanding of the aetiology and pathogenesis of DLB. The impact of peripheral inflammation on the brain in dementia has been increasingly explored in recent years, with T lymphocyte recruitment into brain parenchyma identified in AD and Parkinson's disease. There is now a growing range of literature emerging on the potential role of innate and adaptive immune cells in DLB, including T lymphocytes. In this review, we examine the profile of T lymphocytes in DLB, focusing on studies of post-mortem brain tissue, cerebrospinal fluid, and the blood compartment. We present an integrated viewpoint on the results of these studies by proposing how changes to the T lymphocyte profile in the brain and periphery may relate to each other. Improving our understanding of T lymphocytes in DLB has the potential to guide the development of disease-modifying treatments.
路易体痴呆（DLB）是导致痴呆的第二常见神经退行性病因。与阿尔茨海默病（AD）相比，DLB患者的预后较差，但这两种疾病在神经病理学和临床综合征方面存在重叠。我们必须加深对DLB病因和发病机制的理解。近年来，外周炎症对痴呆大脑的影响受到越来越多的探索，在AD和帕金森病中已发现T淋巴细胞募集到脑实质中。现在，关于先天性和适应性免疫细胞（包括T淋巴细胞）在DLB中的潜在作用的文献越来越多。在这篇综述中，我们研究了DLB中T淋巴细胞的特征，重点关注对死后脑组织、脑脊液和血液成分的研究。我们通过提出大脑和外周T淋巴细胞特征的变化可能如何相互关联，对这些研究结果提出了一个综合观点。增进我们对DLB中T淋巴细胞的理解有可能指导疾病修饰治疗的发展。
