Liang Peigang, Zhang Jiaqi, Wang Bo
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.
Shenzhen Research Institute of Xiamen University, Shenzhen 518057, China.
Cells. 2023 Sep 21;12(18):2329. doi: 10.3390/cells12182329.
Biomolecular condensates are dynamic non-membrane-bound macromolecular high-order assemblies that participate in a growing list of cellular processes, such as transcription, the cell cycle, etc. Disturbed dynamics of biomolecular condensates are associated with many diseases, including cancer and neurodegeneration. Extensive efforts have been devoted to uncovering the molecular and biochemical grammar governing the dynamics of biomolecular condensates and establishing the critical roles of protein posttranslational modifications (PTMs) in this process. Here, we summarize the regulatory roles of ubiquitination (a major form of cellular PTM) in the dynamics of biomolecular condensates. We propose that these regulatory mechanisms can be harnessed to combat many diseases.
生物分子凝聚物是动态的无膜结合大分子高阶聚集体，参与越来越多的细胞过程，如转录、细胞周期等。生物分子凝聚物的动力学紊乱与许多疾病相关，包括癌症和神经退行性疾病。人们已经付出了大量努力来揭示控制生物分子凝聚物动力学的分子和生化规律，并确定蛋白质翻译后修饰（PTM）在此过程中的关键作用。在这里，我们总结了泛素化（细胞PTM的主要形式）在生物分子凝聚物动力学中的调节作用。我们认为，可以利用这些调节机制来对抗许多疾病。
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