Chen Dengwang, Ji Qinglu, Liu Jing, Cheng Feng, Zheng Jishan, Ma Yunyan, He Yuqi, Zhang Jidong, Song Tao
Department of Immunology, Zunyi Medical University, Zunyi 563002, China.
School of Pharmacy, Zunyi Medical University, Zunyi 563002, China.
Biomolecules. 2023 Sep 4;13(9):1344. doi: 10.3390/biom13091344.
The retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) play a crucial role as pattern-recognition receptors within the innate immune system. These receptors, present in various cell and tissue types, serve as essential sensors for viral infections, enhancing the immune system's capacity to combat infections through the induction of type I interferons (IFN-I) and inflammatory cytokines. RLRs are involved in a variety of physiological and pathological processes, including viral infections, autoimmune disorders, and cancer. An increasing body of research has examined the possibility of RLRs or microRNAs as therapeutic targets for antiviral infections and malignancies, despite the fact that few studies have focused on the regulatory function of microRNAs on RLR signaling. Consequently, our main emphasis in this review is on elucidating the role of microRNAs in modulating the signaling pathways of RLRs in the context of cancer and viral infections. The aim is to establish a robust knowledge base that can serve as a basis for future comprehensive investigations into the interplay between microRNAs and RIG-I, while also facilitating the advancement of therapeutic drug development.
视黄酸诱导基因I（RIG-I）样受体（RLRs）作为固有免疫系统中的模式识别受体发挥着关键作用。这些受体存在于各种细胞和组织类型中，是病毒感染的重要传感器，通过诱导I型干扰素（IFN-I）和炎性细胞因子来增强免疫系统对抗感染的能力。RLRs参与多种生理和病理过程，包括病毒感染、自身免疫性疾病和癌症。尽管很少有研究关注微小RNA对RLR信号传导的调节功能，但越来越多的研究探讨了将RLRs或微小RNA作为抗病毒感染和恶性肿瘤治疗靶点的可能性。因此，我们在本综述中的主要重点是阐明微小RNA在癌症和病毒感染背景下调节RLR信号通路中的作用。目的是建立一个强大的知识库，可为未来对微小RNA与RIG-I之间相互作用的全面研究提供基础，同时也促进治疗药物开发的进展。
