Wu Laidi, Liu Zhixin, Xiao Li, Ai Mi, Cao Yingguang, Mao Jing, Song Ke
Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Prosthodontics and Implantology, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Biomolecules. 2023 Sep 5;13(9):1351. doi: 10.3390/biom13091351.
Glioma-associated oncogene homolog 1 (Gli1) is a transcriptional activator of hedgehog (Hh) signaling that regulates target gene expression and several cellular biological processes. Cell lineage tracing techniques have highlighted Gli1 as an ideal marker for mesenchymal stem cells (MSCs) in vivo. Gli1 MSCs are critical for the osteogenesis of the craniofacial bone; however, the regulatory mechanism by which Gli1 MSCs mediate the bone development and tissue regeneration of craniofacial bone has not been systematically outlined. This review comprehensively elucidates the specific roles of Gli1 MSCs in craniofacial bone osteogenesis. In addition to governing craniofacial bone development, Gli1 MSCs are associated with the tissue repair of craniofacial bone under pathological conditions. Gli1 MSCs promote intramembranous and endochondral ossification of the craniofacial bones, and assist the osteogenesis of the craniofacial bone by improving angiopoiesis. This review summarizes the novel role of Gli1 MSCs in bone development and tissue repair in craniofacial bones, which offers new insights into bone regeneration therapy.
胶质瘤相关癌基因同源物1（Gli1）是一种刺猬信号通路（Hh）的转录激活因子，可调节靶基因表达及多个细胞生物学过程。细胞谱系追踪技术已将Gli1确定为体内间充质干细胞（MSC）的理想标志物。Gli1 MSC对颅面骨的成骨作用至关重要；然而，Gli1 MSC介导颅面骨骨发育和组织再生的调控机制尚未得到系统阐述。本综述全面阐明了Gli1 MSC在颅面骨成骨中的具体作用。除了调控颅面骨发育外，Gli1 MSC还与病理条件下颅面骨的组织修复有关。Gli1 MSC促进颅面骨的膜内成骨和软骨内成骨，并通过改善血管生成来协助颅面骨的成骨作用。本综述总结了Gli1 MSC在颅面骨骨发育和组织修复中的新作用，为骨再生治疗提供了新的见解。
