Wang Dan, Xiang Yayun, Peng Yuling, Zeng Peng, Zeng Bang, Chai Ying, Li Yongmei
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, China.
Department of Radiology, Mianyang Central Hospital, 12# Changjia Lane, Mianyang 621000, China.
Brain Sci. 2023 Sep 13;13(9):1315. doi: 10.3390/brainsci13091315.
To explore the performance of deep medullary vein (DMV) and magnetic resonance imaging (MRI) markers in different intracerebral hemorrhage (ICH) subtypes in patients with cerebral small vessel disease (CSVD).
In total, 232 cases of CSVD with ICH were included in this study. The clinical and image data were retrospectively analyzed. Patients were divided into hypertensive arteriopathy (HTNA)-related ICH, cerebral amyloid angiopathy (CAA)-related ICH, and mixed ICH groups. The DMV score was determined in the cerebral hemisphere contralateral to the ICH.
The DMV score was different between the HTNA-related and mixed ICH groups ( < 0.01). The MRI markers and CSVD burden score were significant among the ICH groups ( < 0.05). Compared to mixed ICH, HTNA-related ICH diagnosis was associated with higher deep white matter hyperintensity (DWMH) (OR: 0.452, 95% CI: 0.253-0.809, < 0.05) and high-degree perivascular space (PVS) (OR: 0.633, 95% CI: 0.416-0.963, < 0.05), and CAA-related ICH diagnosis was associated with increased age (OR: 1.074; 95% CI: 1.028-1.122, = 0.001). The DMV score correlated with cerebral microbleed (CMB), PVS, DWMH, periventricular white matter hyperintensity (PWMH), and CSVD burden score ( < 0.05) but not with lacuna ( > 0.05). Age was an independent risk factor for the severity of DMV score (OR: 1.052; 95% CI: 0.026-0.076, < 0.001).
DMV scores, CSVD markers, and CSVD burden scores were associated with different subtypes of ICH. In addition, DMV scores were associated with the severity of CSVD and CSVD markers.
探讨脑小血管病（CSVD）患者不同脑出血（ICH）亚型中深髓静脉（DMV）和磁共振成像（MRI）标志物的表现。
本研究共纳入232例CSVD合并ICH患者。对临床和影像数据进行回顾性分析。患者分为高血压性动脉病变（HTNA）相关ICH、脑淀粉样血管病（CAA）相关ICH和混合性ICH组。在ICH对侧大脑半球确定DMV评分。
HTNA相关ICH组和混合性ICH组之间的DMV评分不同（<0.01）。MRI标志物和CSVD负担评分在ICH组之间有显著差异（<0.05）。与混合性ICH相比，HTNA相关ICH诊断与更高的深部白质高信号（DWMH）（OR：0.452，95%CI：0.253 - 0.809，<0.05）和高度血管周围间隙（PVS）（OR：0.633，95%CI：0.416 - 0.963，<0.05）相关，而CAA相关ICH诊断与年龄增加相关（OR：1.074；95%CI：1.028 - 1.122，=0.001）。DMV评分与脑微出血（CMB）、PVS、DWMH、脑室周围白质高信号（PWMH）和CSVD负担评分相关（<0.05），但与腔隙无关（>0.05）。年龄是DMV评分严重程度的独立危险因素（OR：1.052；95%CI：0.026 - 0.076，<0.001）。
DMV评分、CSVD标志物和CSVD负担评分与不同亚型的ICH相关。此外，DMV评分与CSVD的严重程度和CSVD标志物相关。
