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脑小血管病的MRI可见血管周围间隙与其他MRI标志物的关系。

Relation of MRI-Visible Perivascular Spaces and Other MRI Markers of Cerebral Small Vessel Disease.

作者信息

Rodriguez Lara Frances, Toro Arturo Ruben, Pinheiro Adlin, Demissie Serkalem, Ekenze Oluchi, Martinez Oliver, Parva Pedram, Charidimou Andreas, Ghosh Saptaparni, DeCarli Charles, Seshadri Sudha, Habes Mohamad, Maillard Pauline, Romero Jose Rafael

机构信息

Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.

Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA.

出版信息

Brain Sci. 2023 Sep 14;13(9):1323. doi: 10.3390/brainsci13091323.

DOI:10.3390/brainsci13091323
PMID:37759924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10527297/
Abstract

Perivascular spaces (PVS) visible on brain MRI signal cerebral small vessel disease (CSVD). The coexistence of PVS with other CSVD manifestations likely increases the risk of adverse neurological outcomes. We related PVS to other CSVD manifestations and brain volumes that are markers of vascular brain injury and neurodegeneration. Framingham Heart Study (FHS) participants with CSVD ratings on brain MRI were included. PVS were rated in the basal ganglia (BG) and centrum semiovale (CSO) into grades I-IV and a category reflecting high burden in single or mixed CSO-BG regions. We related PVS to covert brain infarcts (CBI), white matter hyperintensities (WMH), cerebral microbleeds (CMB), total brain, hippocampal, and cortical gray matter volumes using adjusted multivariable regression analyses. In 2454 participants (mean age 54 ± 12 years), we observed that higher PVS burden in both BG and CSO was related to CMB in lobar and deep brain regions and increased WMH. Greater CSO PVS burden was associated with decreased total cortical gray volumes. PVS are associated with ischemic markers of CSVD and neurodegeneration markers. Further studies should elucidate the causality between PVS and other CSVD manifestations.

摘要

脑磁共振成像（MRI）上可见的血管周围间隙（PVS）提示脑小血管病（CSVD）。PVS与其他CSVD表现共存可能会增加不良神经结局的风险。我们将PVS与其他CSVD表现以及作为血管性脑损伤和神经退行性变标志物的脑容量进行了关联研究。纳入了在脑MRI上有CSVD评分的弗雷明汉心脏研究（FHS）参与者。对基底节（BG）和半卵圆中心（CSO）的PVS进行分级，分为I-IV级以及反映单个或混合CSO-BG区域高负荷的类别。我们使用校正后的多变量回归分析将PVS与隐匿性脑梗死（CBI）、白质高信号（WMH）、脑微出血（CMB）、全脑、海马和皮质灰质体积进行关联。在2454名参与者（平均年龄54±12岁）中，我们观察到BG和CSO中较高的PVS负荷与脑叶和深部脑区的CMB以及增加的WMH相关。CSO中更大的PVS负荷与总皮质灰质体积减少相关。PVS与CSVD的缺血标志物和神经退行性变标志物相关。进一步的研究应阐明PVS与其他CSVD表现之间的因果关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/114e7c505683/brainsci-13-01323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/6469cdf16c24/brainsci-13-01323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/133e914cff75/brainsci-13-01323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/114e7c505683/brainsci-13-01323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/6469cdf16c24/brainsci-13-01323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/133e914cff75/brainsci-13-01323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f1/10527297/114e7c505683/brainsci-13-01323-g003.jpg

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