Munteanu Constantin, Turnea Marius Alexandru, Rotariu Mariana
Teaching Emergency Hospital "Bagdasar-Arseni" (TEHBA), 041915 Bucharest, Romania.
Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" Iași, 700454 Iași, Romania.
Antioxidants (Basel). 2023 Sep 7;12(9):1737. doi: 10.3390/antiox12091737.
Hydrogen sulfide (HS), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of HS and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of HS, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating HS's roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of HS in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of HS in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness HS's potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize HS's pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.
硫化氢（HS）传统上被认为是一种有毒气体，但它已成为许多生物过程中的关键调节因子，包括氧化应激和细胞稳态。本综述全面概述了目前对HS及其在哺乳动物细胞功能和氧化应激管理中的多方面作用的理解。我们深入探讨了HS的生物来源和功能、氧化应激和细胞稳态的潜在机制，以及这些过程之间的复杂关系。我们研究了近期实验和临床研究的证据，揭示了决定HS在调节氧化应激反应和维持细胞稳态中作用的复杂生化和分子机制。讨论了HS在以氧化应激失调和内环境稳态破坏为特征的疾病中的临床意义和治疗潜力，突出了HS在健康和疾病中的新重要性。最后，本综述强调了该领域当前的挑战、争议和未来方向，强调需要进一步研究以利用HS作为与氧化应激和内环境稳态失衡相关疾病的治疗剂的潜力。通过本综述，我们旨在强调HS在细胞功能中的关键作用，鼓励对这一新兴研究领域进行进一步探索。
