Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Biomolecules. 2023 Jun 21;13(7):1023. doi: 10.3390/biom13071023.
Hydrogen sulfide (HS) is an endogenous gasotransmitter that promotes multiple biological effects in many organs and tissues. An imbalanced biosynthesis of HS has been observed in animal models of age-related pathological conditions. However, the results from human studies are inconsistent. We performed a systematic review with meta-analysis of studies searched in Medline, Embase, Scopus, and CENTRAL databases. We included observational studies on patients with age-related diseases showing levels of HS in blood, plasma, or serum. All the analyses were carried out with R software. 31 studies were included in the systematic review and 21 in the meta-analysis. The circulating levels of HS were significantly reduced in patients with progressive, chronic, and degenerative diseases compared with healthy people (standardized mean difference, SMD: -1.25; 95% confidence interval, CI: -1.98; -0.52). When we stratified results by type of disorder, we observed a significant reduction in circulating levels of HS in patients with vascular disease (e.g., hypertension) (SMD: -1.32; 95% CI: -2.43; -0.22) or kidney disease (SMD: -2.24; 95% CI: -4.40; -0.08) compared with the control group. These results could support the potential use of compounds targeting the "HS system" to slow down the progression of many diseases in the elderly.
硫化氢（HS）是一种内源性气体递质，可促进许多器官和组织的多种生物学效应。在与年龄相关的病理条件的动物模型中观察到 HS 的生物合成不平衡。然而，来自人类研究的结果并不一致。我们对 Medline、Embase、Scopus 和 CENTRAL 数据库中搜索的研究进行了系统评价和荟萃分析。我们纳入了显示血液、血浆或血清中 HS 水平的与年龄相关疾病患者的观察性研究。所有分析均使用 R 软件进行。系统评价纳入了 31 项研究，荟萃分析纳入了 21 项研究。与健康人相比，进展性、慢性和退行性疾病患者的循环 HS 水平显著降低（标准化均数差，SMD：-1.25；95%置信区间，CI：-1.98；-0.52）。当我们按疾病类型对结果进行分层时，我们观察到血管疾病（如高血压）（SMD：-1.32；95% CI：-2.43；-0.22）或肾脏疾病（SMD：-2.24；95% CI：-4.40；-0.08）患者的循环 HS 水平与对照组相比显著降低。这些结果可能支持使用靶向“HS 系统”的化合物来减缓老年人许多疾病的进展。
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