Sokol Olga, Durante Marco
Biophysics Department, GSI Helmholtzzentrum für Schwerionenforchung, Planckstraße 1, 64291 Darmstadt, Germany.
Institute for Condensed Matter Physics, Technische Universität Darmstadt, Hochschulstraße 8, 64289 Darmstadt, Germany.
Cancers (Basel). 2023 Sep 9;15(18):4494. doi: 10.3390/cancers15184494.
Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors.
缺氧与异常血管生成相关，是许多实体瘤的一个特征，它会增加肿瘤的转移潜能和对放疗的抗性。碳离子放射治疗，无论是单独使用还是与其他治疗方法联合使用，都是治疗缺氧肿瘤最有前景的方法之一，因为随着粒子传能线密度（LET）增加，氧增强比会降低。然而，目前的临床实践尚未充分受益于使用碳离子来应对缺氧问题。在此，我们概述了支持碳离子放射治疗在克服缺氧诱导的放射抗性方面疗效的现有实验和临床证据，随后讨论了为增强其疗效而提出的策略，包括在肿瘤中最大化LET的不同方法。
