超高剂量率氧离子放射治疗的首次体外和体内实验。

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy.

作者信息

Karle Celine, Filosa Domenico I, Akbarpour Mahdi, Schuhmacher Nora, Brons Stephan, Cee Rainer, Schömers Christian, Scheloske Stefan, Petersson Kristoffer, Haberer Thomas, Abdollahi Amir, Debus Jürgen, Tessonnier Thomas, Moustafa Mahmoud, Mairani Andrea, Dokic Ivana

机构信息

Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, Heidelberg, Germany.

Department of Physics and Astronomy, Heidelberg University, Im Neuenheimer Feld 226, 69120 Heidelberg, Germany.

出版信息

Phys Imaging Radiat Oncol. 2025 Jul 3;35:100803. doi: 10.1016/j.phro.2025.100803. eCollection 2025 Jul.

DOI:10.1016/j.phro.2025.100803

PMID:40698313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12280408/

Abstract

Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in a protein-enriched saline solution. For the studied conditions of dose, dose rate and linear energy transfer (LET), UHDR irradiation showed comparable efficacy to SDR in pancreatic cancer cell killing in vitro, along with inducing a similar tumor growth delay in vivo. These findings emphasize the potential of high-LET UHDR irradiation and support further investigation of oxygen ions at UHDR.

摘要

在本研究中，我们证明了在三种不同生物复杂程度水平下进行超高剂量率（UHDR）氧离子辐照的可行性。在富含蛋白质的盐溶液中，UHDR与标准剂量率（SDR）之间的耗氧量差异可忽略不计。对于所研究的剂量、剂量率和线能量转移（LET）条件，UHDR辐照在体外杀死胰腺癌细胞方面显示出与SDR相当的疗效，同时在体内诱导相似的肿瘤生长延迟。这些发现强调了高LET UHDR辐照的潜力，并支持对UHDR条件下的氧离子进行进一步研究。