[抗结核药治疗后大鼠红细胞中葡萄糖利用及葡萄糖-6-磷酸脱氢酶、异柠檬酸脱氢酶和苹果酸脱氢酶的活性]
[Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents].
作者信息
Storozhuk P G, Skliar V A, Korochanskaia S P, Gontmakher Iu V
出版信息
Vopr Med Khim. 1986 Sep-Oct;32(5):32-5.
Metazamide, phthivazid, larusan and rifamycin were shown to inhibit activities of glucose-6-phosphate-, isocitrate- and malate dehydrogenases in male rats within 10-14 days by 14-32%; as a result of this, the rate of glucose consumption was decreased in blood, as shown by the shape of sugar plots after loading with 300 mg of glucose. Administration of these drugs led to elevation of sugar curves by 11-18% as compared with controls. p-Amino-salicylic acid, isoniazid and protionamide inhibited the enzymatic activity but affected the rate of glucose consumption only slightly. Ethambutal activated these enzymes by 13-29%; the highest rate of glucose consumption was observed in presence of the drug.
已表明，美他酰胺、酞酰肼、拉鲁山和利福霉素在10至14天内可使雄性大鼠体内的葡萄糖-6-磷酸脱氢酶、异柠檬酸脱氢酶和苹果酸脱氢酶的活性受到抑制，抑制率为14%至32%；结果，血液中葡萄糖的消耗速率降低，这从给300毫克葡萄糖后血糖曲线的形状可以看出。与对照组相比，使用这些药物后血糖曲线升高了11%至18%。对氨基水杨酸、异烟肼和丙硫异烟胺抑制酶活性，但对葡萄糖消耗速率影响甚微。乙胺丁醇使这些酶的活性提高了13%至29%；在有该药物存在的情况下观察到最高的葡萄糖消耗速率。
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