Saji Shota, Hasegawa Junichi, Koike Junki, Takatsuki Misato, Furuya Natsumi, Suzuki Nao
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
Department of Pathology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
Diagnostics (Basel). 2023 Sep 18;13(18):2977. doi: 10.3390/diagnostics13182977.
Fetal Vascular Malperfusion (FVM), a pathologic condition in the feto-placental circulation, is a chronic vaso-occlusive disorder in the umbilical venous blood flow. Microthrombi are caused by the umbilical cord's blood flow deficiency in a congested umbilical vein, which also causes microvascular damage to fetal organs, especially the brain, resulting in cerebral palsy. Thrombo-occlusive events also adversely affect the upstream chorionic or stem vessels in the placenta, resulting in fetal growth restriction and fetal hypoxia. An umbilical cord structural anomaly or multiple entanglements may involve FVM. In the present report, we demonstrate a case of FVM caused by multiple umbilical cord abnormalities obtained from antenatal ultrasound Doppler findings, and we also discuss FVM, which is chronically associated with CP, comparing the ultrasonographic findings to the pathologic findings.
胎儿血管灌注不良（FVM）是胎儿 - 胎盘循环中的一种病理状况，是脐静脉血流中的一种慢性血管闭塞性疾病。微血栓由脐静脉充血时脐带血流不足引起，这也会导致胎儿器官尤其是脑部的微血管损伤，进而导致脑瘫。血栓闭塞事件还会对胎盘上游的绒毛膜或主干血管产生不利影响，导致胎儿生长受限和胎儿缺氧。脐带结构异常或多处缠绕可能与FVM有关。在本报告中，我们展示了一例由产前超声多普勒检查发现的多处脐带异常引起的FVM病例，并且我们还讨论了与脑瘫长期相关的FVM，将超声检查结果与病理检查结果进行了比较。
