Yeast Physiology Group, Departamento de Genética y Microbiología, Facultad de Biología, Universidad de Murcia, 30100 Murcia, Spain.
Int J Mol Sci. 2023 Sep 7;24(18):13827. doi: 10.3390/ijms241813827.
Autophagy, the process that enables the recycling and degradation of cellular components, is essential for homeostasis, which occurs in response to various types of stress. Autophagy plays an important role in the genesis and evolution of osteosarcoma (OS). The conventional treatment of OS has limitations and is not always effective at controlling the disease. Therefore, numerous researchers have analyzed how controlling autophagy could be used as a treatment or strategy to reverse resistance to therapy in OS. They highlight how the inhibition of autophagy improves the efficacy of chemotherapeutic treatments and how the promotion of autophagy could prove positive in OS therapy. The modulation of autophagy can also be directed against OS stem cells, improving treatment efficacy and preventing cancer recurrence. Despite promising findings, future studies are needed to elucidate the molecular mechanisms of autophagy and its relationship to OS, as well as the mechanisms underlying the functioning of autophagic modulators. Careful evaluation is required as autophagy modulation may have adverse effects on normal cells, and the optimization of autophagic modulators for use as drugs in OS is imperative.
自噬是一种使细胞成分回收和降解的过程，对于维持内稳态至关重要，内稳态是对各种类型的应激的反应。自噬在骨肉瘤（OS）的发生和发展中起着重要作用。OS 的传统治疗方法存在局限性，并不总是能有效地控制疾病。因此，许多研究人员分析了如何控制自噬可以作为治疗或逆转 OS 治疗耐药性的策略。他们强调了自噬抑制如何提高化疗治疗的疗效，以及自噬促进如何在 OS 治疗中证明是积极的。自噬的调节也可以针对 OS 干细胞，提高治疗效果并预防癌症复发。尽管有有希望的发现，但仍需要进一步的研究来阐明自噬的分子机制及其与 OS 的关系，以及自噬调节剂作用的机制。需要仔细评估，因为自噬调节可能对正常细胞产生不良影响，并且优化自噬调节剂作为 OS 药物的使用是至关重要的。
