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骨肉瘤中自噬的研究趋势与未来方向：一项文献计量分析

Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis.

作者信息

Shang JinXiang, Zhao FeiYing, Xie Lu, Wang YaQing, Li Bo, Jin Cong

机构信息

Department of Orthopedics, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China.

Department of Sterilization and Supply Center, Zhuji People's Hospital of Zhejiang Province, Shaoxing, Zhejiang, China.

出版信息

Open Med (Wars). 2024 Dec 3;19(1):20241080. doi: 10.1515/med-2024-1080. eCollection 2024.

DOI:10.1515/med-2024-1080
PMID:39655055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11627063/
Abstract

BACKGROUND

Osteosarcoma, a highly malignant skeletal tumor, primarily affects children and adolescents. Autophagy plays a crucial role in osteosarcoma pathophysiology. This study utilizes bibliometric analysis to evaluate current research on autophagy in osteosarcoma and forecast future directions.

METHODS

We conducted a comprehensive search of publications in the Web of Science Core Collection database from January 1, 2008, to March 15, 2024. Tools like VOSviewer, CiteSpace, R software, Excel, and Scimago were used for analysis and visualization.

RESULTS

Publications increased steadily over 17 years, indicating rising interest. Zhang Yuan was the most influential author, with Shanghai Jiao Tong University leading. was the top journal. "HMGB1 Promotes Drug Resistance in Osteosarcoma" was the most cited paper. Co-cited articles focused on drug resistance, therapeutic targets, autophagy in cancer, and genomic impacts on immunotherapy. Keywords highlighted invasion, migration, cell death, and breast cancer as research hotspots. Future studies will likely focus on therapeutic innovations and integrated management strategies.

CONCLUSION

This bibliometric analysis offers an overview of current knowledge and emerging trends in autophagy and osteosarcoma, emphasizing key areas like invasion, migration, and cell death. It serves as a valuable resource for researchers developing novel therapies for osteosarcoma.

摘要

背景

骨肉瘤是一种高度恶性的骨骼肿瘤，主要影响儿童和青少年。自噬在骨肉瘤的病理生理学中起着至关重要的作用。本研究利用文献计量分析来评估目前关于骨肉瘤自噬的研究，并预测未来的研究方向。

方法

我们对2008年1月1日至2024年3月15日期间Web of Science核心合集数据库中的出版物进行了全面检索。使用VOSviewer、CiteSpace、R软件、Excel和Scimago等工具进行分析和可视化。

结果

17年间出版物稳步增加，表明关注度不断提高。张元是最具影响力的作者，上海交通大学处于领先地位。 是顶级期刊。“HMGB1促进骨肉瘤的耐药性”是被引用最多的论文。共被引文章聚焦于耐药性、治疗靶点、癌症中的自噬以及基因组对免疫治疗的影响。关键词突出了侵袭、迁移、细胞死亡和乳腺癌作为研究热点。未来的研究可能会集中在治疗创新和综合管理策略上。

结论

这项文献计量分析概述了自噬与骨肉瘤的当前知识和新趋势，强调了侵袭、迁移和细胞死亡等关键领域。它为开发骨肉瘤新疗法的研究人员提供了宝贵的资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/9b5ffa96ae52/j_med-2024-1080-fig011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/9b5ffa96ae52/j_med-2024-1080-fig011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/0751e52b4afa/j_med-2024-1080-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/d0b89dbe3bef/j_med-2024-1080-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/489bda3ad127/j_med-2024-1080-fig004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/4cac00d78a25/j_med-2024-1080-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/4fd226412d43/j_med-2024-1080-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/3585d4d13793/j_med-2024-1080-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/d222b8a0fc37/j_med-2024-1080-fig009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/6a1c3a143f9c/j_med-2024-1080-fig010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d39e/11627063/9b5ffa96ae52/j_med-2024-1080-fig011.jpg

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