Yang Xinbing, Du Yajing, Luo Lulu, Xu Xinru, Xiong Shizheng, Yang Xueni, Guo Li, Liang Tingming
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, China.
Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
Int J Mol Sci. 2023 Sep 10;24(18):13909. doi: 10.3390/ijms241813909.
Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. These ncRNAs can act as either oncogenes or tumor suppressors, thereby serving as valuable diagnostic and prognostic markers. Numerous studies have implicated the participation of ncRNAs in the regulation of diverse signaling pathways, including the pivotal Wnt/β-catenin signaling pathway that is widely acknowledged for its pivotal role in embryogenesis, cellular proliferation, and tumor biology control. Recent emerging evidence has shed light on the capacity of ncRNAs to interact with key components of the Wnt/β-catenin signaling pathway, thereby modulating the expression of Wnt target genes in cancer cells. Notably, the activity of this pathway can reciprocally influence the expression levels of ncRNAs. However, comprehensive analysis investigating the specific ncRNAs associated with the Wnt/β-catenin signaling pathway and their intricate interactions in cancer remains elusive. Based on these noteworthy findings, this review aims to unravel the intricate associations between ncRNAs and the Wnt/β-catenin signaling pathway during cancer initiation, progression, and their potential implications for therapeutic interventions. Additionally, we provide a comprehensive overview of the characteristics of ncRNAs and the Wnt/β-catenin signaling pathway, accompanied by a thorough discussion of their functional roles in tumor biology. Targeting ncRNAs and molecules associated with the Wnt/β-catenin signaling pathway may emerge as a promising and effective therapeutic strategy in future cancer treatments.
特定非编码RNA（ncRNA）的表达失调与肿瘤发生、癌症进展及治疗耐药性密切相关。这些ncRNA既可作为癌基因，也可作为肿瘤抑制因子，因此是有价值的诊断和预后标志物。众多研究表明，ncRNA参与多种信号通路的调控，包括关键的Wnt/β-连环蛋白信号通路，该通路因其在胚胎发育、细胞增殖及肿瘤生物学控制中的关键作用而广为人知。最近新出现的证据揭示了ncRNA与Wnt/β-连环蛋白信号通路关键成分相互作用的能力，从而调节癌细胞中Wnt靶基因的表达。值得注意的是，该通路的活性可反过来影响ncRNA的表达水平。然而，全面分析与Wnt/β-连环蛋白信号通路相关的特定ncRNA及其在癌症中的复杂相互作用仍不明确。基于这些值得关注的发现，本综述旨在揭示癌症发生、发展过程中ncRNA与Wnt/β-连环蛋白信号通路之间的复杂关联及其对治疗干预的潜在影响。此外，我们全面概述了ncRNA和Wnt/β-连环蛋白信号通路的特征，并深入讨论了它们在肿瘤生物学中的功能作用。靶向与Wnt/β-连环蛋白信号通路相关的ncRNA和分子可能成为未来癌症治疗中一种有前景且有效的治疗策略。
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