School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Cell Commun Signal. 2023 Jun 29;21(1):166. doi: 10.1186/s12964-023-01092-6.
During the past decades, gastric cancer (GC) has emerged as one of the most frequent malignancies with a growing rate of prevalence around the world. Despite considerable advances in therapeutic methods, the prognosis and management of patients with gastric cancer (GC) continue to be poor. As one of the candidate molecular targets in the treatment of many types of cancer, the Wnt/β-catenin pathway includes a family of proteins that have important functions in adult tissue homeostasis and embryonic development. The aberrant regulation of Wnt/β-catenin signaling is strongly correlated with the initiation and development of numerous cancers, including GC. Therefore, Wnt/β-catenin signaling has been identified as one of the main targets for extending therapeutic approaches for GC patients. Non-coding RNAs (ncRNAs), including microRNAs and long ncRNAs, are important components of epigenetic mechanisms in gene regulation. They play vital roles in various molecular and cellular processes and regulate many signaling pathways, such as Wnt/β-catenin pathways. Insights into these regulatory molecules involved in GC development may lead to the identification of potential targets for overcoming the limitations of current therapeutic approaches. Consequently, this review aimed to provide a comprehensive overview of ncRNAs interactions involved in Wnt/β-catenin pathway function in GC with diagnostic and therapeutic perspectives. Video Abstract.
在过去的几十年中，胃癌（GC）已成为全球发病率不断上升的最常见恶性肿瘤之一。尽管治疗方法取得了相当大的进展，但胃癌（GC）患者的预后和治疗仍不容乐观。Wnt/β-catenin 通路作为治疗多种癌症的候选分子靶点之一，包括一组在成人组织稳态和胚胎发育中具有重要功能的蛋白质。Wnt/β-catenin 信号通路的异常调节与包括 GC 在内的许多癌症的发生和发展密切相关。因此，Wnt/β-catenin 信号通路已被确定为延长 GC 患者治疗方法的主要靶点之一。非编码 RNA（ncRNA），包括 microRNAs 和长 ncRNAs，是基因调控中表观遗传机制的重要组成部分。它们在各种分子和细胞过程中发挥重要作用，并调节许多信号通路，如 Wnt/β-catenin 通路。对这些参与 GC 发生的调控分子的深入了解可能会为克服当前治疗方法的局限性找到潜在的靶点。因此，本综述旨在从诊断和治疗的角度全面概述参与 GC 中 Wnt/β-catenin 通路功能的 ncRNA 相互作用。
