Bu Tong, Li Le, Tian Jiyu
Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Front Pharmacol. 2023 Sep 27;14:1269233. doi: 10.3389/fphar.2023.1269233. eCollection 2023.
Prostate cancer (PCa) is one of the most common cancers in males, exhibiting a wide spectrum of clinical manifestations that pose challenges in its diagnosis and treatment. The Wnt signaling pathway, a conserved and complex pathway, is crucial for embryonic development, tissue homeostasis, and various physiological processes. Apart from the classical Wnt/β-catenin signaling pathway, there exist multiple non-classical Wnt signaling pathways, including the Wnt/PCP and Wnt/Ca pathways. Non-coding RNAs (ncRNAs) are involved in the occurrence and development of PCa and the response to PCa treatment. ncRNAs are known to execute diverse regulatory roles in cellular processes, despite their inability to encode proteins. Among them, microRNAs, long non-coding RNAs, and circular RNAs play key roles in the regulation of the Wnt signaling pathway in PCa. Aberrant expression of these ncRNAs and dysregulation of the Wnt signaling pathway are one of the causes of cell proliferation, apoptosis, invasion, migration, and angiogenesis in PCa. Moreover, these ncRNAs affect the characteristics of PCa cells and hold promise as diagnostic and prognostic biomarkers. Herein, we summarize the role of ncRNAs in the regulation of the Wnt signaling pathway during the development of PCa. Additionally, we present an overview of the current progress in research on the correlation between these molecules and clinical features of the disease to provide novel insights and strategies for the treatment of PCa.
前列腺癌（PCa）是男性最常见的癌症之一，其临床表现多种多样，给诊断和治疗带来挑战。Wnt信号通路是一条保守且复杂的通路，对胚胎发育、组织稳态及各种生理过程至关重要。除经典的Wnt/β-连环蛋白信号通路外，还存在多种非经典Wnt信号通路，包括Wnt/PCP和Wnt/Ca通路。非编码RNA（ncRNAs）参与了PCa的发生发展及对PCa治疗的反应。尽管ncRNAs不能编码蛋白质，但已知它们在细胞过程中发挥多种调控作用。其中，微小RNA、长链非编码RNA和环状RNA在PCa中Wnt信号通路的调控中起关键作用。这些ncRNAs的异常表达和Wnt信号通路的失调是PCa细胞增殖、凋亡、侵袭、迁移和血管生成的原因之一。此外，这些ncRNAs影响PCa细胞的特性，有望成为诊断和预后生物标志物。在此，我们总结了ncRNAs在PCa发生发展过程中对Wnt信号通路调控的作用。此外，我们概述了这些分子与该疾病临床特征之间相关性的研究进展，为PCa的治疗提供新的见解和策略。
