Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Int J Mol Sci. 2023 Sep 12;24(18):13985. doi: 10.3390/ijms241813985.
Cancer is one of the major diseases that seriously threaten human life. Traditional anticancer therapies have achieved remarkable efficacy but have also some unavoidable side effects. Therefore, more and more research focuses on highly effective and less-toxic anticancer substances of natural origin. Amphibian skin is rich in active substances such as biogenic amines, alkaloids, alcohols, esters, peptides, and proteins, which play a role in various aspects such as anti-inflammatory, immunomodulatory, and anticancer functions, and are one of the critical sources of anticancer substances. Currently, a range of natural anticancer substances are known from various amphibians. This paper aims to review the physicochemical properties, anticancer mechanisms, and potential applications of these peptides and proteins to advance the identification and therapeutic use of natural anticancer agents.
癌症是严重威胁人类生命的主要疾病之一。传统的抗癌疗法已经取得了显著的疗效，但也存在一些不可避免的副作用。因此，越来越多的研究集中在高效低毒的天然来源抗癌物质上。两栖动物的皮肤富含生物胺、生物碱、醇、酯、肽和蛋白质等活性物质，这些物质在抗炎、免疫调节和抗癌功能等方面发挥作用，是抗癌物质的重要来源之一。目前，从各种两栖动物中已经发现了多种天然抗癌物质。本文旨在综述这些肽类和蛋白质的理化性质、抗癌机制及潜在应用，以期促进天然抗癌药物的鉴定和治疗应用。
