1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528 Athens, Greece.
Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41100 Larissa, Greece.
Int J Mol Sci. 2023 Sep 14;24(18):14079. doi: 10.3390/ijms241814079.
Cognitive and physical decline, both indicators of aging, seem to be associated with each other. The aim of the present study was to investigate whether physical function parameters (walking time and handgrip strength) are related to cerebrospinal fluid (CSF) biomarkers (amyloid-beta Aβ, Tau, PhTau) in individuals in the Alzheimer's disease (AD) continuum. The sample was drawn from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration study, comprising 163 individuals aged 40-75 years: 112 cognitively normal (CN) and 51 with mild cognitive impairment (MCI). Physical function parameters were measured at baseline, a lumbar puncture was performed the same day and CSF biomarkers were analyzed using automated methods. The association between walking time, handgrip strength and CSF biomarkers was evaluated by linear correlation, followed by multivariate linear regression models adjusted for age, sex, education and APOEe4 genotype. Walking time was inversely related to CSF Aβ (lower CSF values correspond to increased brain deposition) in all participants ( < 0.05). Subgroup analysis showed that this association was stronger in individuals with MCI and participants older than 60 years old, a result which remained statistically significant after adjustment for the aforementioned confounding factors. These findings may open new perspectives regarding the role of mobility in the AD continuum.
认知和身体功能下降，两者都是衰老的指标，似乎相互关联。本研究旨在探讨身体功能参数（步行时间和握力）是否与阿尔茨海默病（AD）连续体个体的脑脊液（CSF）生物标志物（β淀粉样蛋白 Aβ、Tau、PhTau）相关。该样本来自于 Aiginition 纵向神经退行性变生物标志物研究，包括 163 名年龄在 40-75 岁的个体：112 名认知正常（CN）和 51 名轻度认知障碍（MCI）。在基线时测量身体功能参数，当天进行腰椎穿刺，并使用自动化方法分析 CSF 生物标志物。通过线性相关评估步行时间、握力与 CSF 生物标志物之间的关系，然后使用多元线性回归模型调整年龄、性别、教育程度和 APOEe4 基因型。在所有参与者中，步行时间与 CSF Aβ呈负相关（较低的 CSF 值对应于大脑沉积增加）（<0.05）。亚组分析显示，这种相关性在 MCI 个体和年龄大于 60 岁的参与者中更强，在调整上述混杂因素后，这一结果仍然具有统计学意义。这些发现可能为移动性在 AD 连续体中的作用提供新的视角。
