铅缺乏对脂质代谢的影响。

Effects of lead deficiency on lipid metabolism.

作者信息

Reichlmayr-Lais A M, Kirchgessner M

出版信息

Z Ernahrungswiss. 1986 Sep;25(3):165-70. doi: 10.1007/BF02021248.

DOI:10.1007/BF02021248

Abstract

The criteria of lipid metabolism in lead deficiency were determined. For this purpose an experiment was performed with Sprague-Dawley rats distributed in depletion and control groups. The depletion rats were fed an extremely low lead content diet (20 +/- 5 ppb), whereas the diet for the control animals was supplemented with 800 ppb Pb++. Dependent on generation, depletion influenced triglyceride content in serum and liver, phospholipid and cholesterol content in liver as well as the whole body fat of the offspring. The results indicate that in mothers the absorption of lipids is impaired. Consequently it is possible that the mothers do not excrete enough fat with milk leading to an energetical deficiency and therefore to reduced growth.

摘要

确定了铅缺乏时脂质代谢的标准。为此，对斯普拉格-道利大鼠进行了实验，将其分为缺铅组和对照组。缺铅大鼠喂食铅含量极低的饮食（20±5 ppb），而对照动物的饮食中补充了800 ppb的Pb++。根据代数不同，缺铅影响血清和肝脏中的甘油三酯含量、肝脏中的磷脂和胆固醇含量以及后代的全身脂肪。结果表明，母亲体内脂质的吸收受到损害。因此，母亲可能无法通过乳汁排出足够的脂肪，导致能量不足，从而使生长减缓。