Kirchgessner M, Reichlmayr-Lais A M
Ann Nutr Metab. 1982;26(1):50-5. doi: 10.1159/000176543.
Different metabolite concentrations were determined in serum, liver, and femur of rats from the F1 generation of a lead-depletion experiment with 18 ppb lead in the depletion diet. In serum as well as in liver the protein concentrations were not different between depletion and control rats, whereas the femur of lead-depleted rats the protein concentration was higher than in control animals. A short time after weaning in young rats there was no difference in glucose and glycogen concentrations in liver between depletion group and the control group. On the contrary, in older lead-depleted rats the glucose concentration in liver was reduced. Massive changes in lead deficiency occurred in certain lipid fractions. In comparison with control rats, in lead-deficient rats the concentrations of triglycerides in serum and liver and the concentrations of LDL and phospholipids in liver were reduced. On the contrary, the livers of lead-depleted rats showed a higher cholesterol concentration than those of control animals. However, the cholesterol concentration in sera of lead-depleted rats was reduced.
在一项耗铅实验的F1代大鼠中，测定了血清、肝脏和股骨中不同代谢物的浓度，该实验的耗铅日粮中铅含量为18 ppb。在血清和肝脏中，耗铅大鼠和对照大鼠的蛋白质浓度没有差异，而在耗铅大鼠的股骨中，蛋白质浓度高于对照动物。幼鼠断奶后短时间内，耗铅组和对照组肝脏中的葡萄糖和糖原浓度没有差异。相反，在年龄较大的耗铅大鼠中，肝脏中的葡萄糖浓度降低。某些脂质组分发生了大量的缺铅变化。与对照大鼠相比，缺铅大鼠血清和肝脏中的甘油三酯浓度以及肝脏中的低密度脂蛋白和磷脂浓度降低。相反，耗铅大鼠的肝脏胆固醇浓度高于对照动物。然而，耗铅大鼠血清中的胆固醇浓度降低。
