Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.
Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA.
Int J Mol Sci. 2023 Sep 15;24(18):14147. doi: 10.3390/ijms241814147.
Peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain and projecting to the nucleus accumbens (NAc) of the striatum. We have previously shown that mechanoreceptor activation via whole-body vibration (WBV) ameliorates neuronal and behavioral effects of chronic ethanol exposure. In this study, we employ a similar paradigm to assess the efficacy of WBV as a preventative measure of neuronal and behavioral effects of morphine withdrawal in a Wistar rat model. We demonstrate that concurrent administration of WBV at 80 Hz with morphine over a 5-day period significantly reduced adaptations in VTA GABA neuronal activity and NAc DA release and modulated expression of δ-opioid receptors (DORs) on NAc cholinergic interneurons (CINs) during withdrawal. We also observed a reduction in behavior typically associated with opioid withdrawal. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD) and should be examined translationally in humans.
基于外周机械感受器的治疗方法，如针灸和脊椎按摩疗法，已被证明可以成功调节中脑腹侧被盖区（VTA）起源并投射到纹状体伏隔核（NAc）的中脑边缘多巴胺（DA）系统。我们之前已经表明，通过全身振动（WBV）激活机械感受器可以改善慢性乙醇暴露的神经元和行为影响。在这项研究中，我们采用类似的范式来评估 WBV 作为预防吗啡戒断对 Wistar 大鼠模型中神经元和行为影响的有效性。我们证明，在 5 天的时间内，以 80 Hz 的频率同时给予 WBV 和吗啡，可以显著减少 VTA GABA 神经元活动和 NAc DA 释放的适应性，并在戒断期间调节 NAc 胆碱能中间神经元（CINs）上的 δ-阿片受体（DOR）的表达。我们还观察到与阿片类药物戒断相关的行为减少。WBV 是治疗阿片类药物使用障碍（OUD）的一种很有前途的辅助方法，应该在人类中进行转化研究。
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